Active and inactive orientations of the transmembrane and cytosolic domains of
the erythropoietin receptor dimer
Eero Mantyranta, a Finnish cross-country skier who won two gold medals in the 1964 Olympics, was born with a mutation in
the erythropoietin receptor gene that allows his blood to carry significantly more oxygen than the average person's [source: McCrory].
New pathogenic mechanisms induced by germline
erythropoietin receptor mutations in primary erythrocytosis
Not exact matches
These included genes associated primarily with the vascular changes resulting from oxygen deprivation; namely (a) VEGF and its
receptors Flk - 1 and Flt - 1 [17,56]; and (b)
erythropoietin (EPO) and its
receptor (EPOR)[16].
Induction of nitric oxide by
erythropoietin is mediated by the β common
receptor and requires interaction with VEGF
receptor 2.