Sentences with phrase «escalation study»

«A dose escalation study was conducted to determine the maximum tolerated dose and safety of a single dose of standardized powder extract, uniformly milled curcumin -LRB-

Part one is an open - label, dose escalation study in at least 8 infants for a minimum of 4 weeks.

The Phase 1b / 2a study of ISIS - SMNRx is a multiple - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 15 who are medically stable.

This protocol is a dose escalation study of Ad - hCMV - TK and Ad - hCMV - Flt3L infused at the time of surgical resection followed by systemic oral administration of valacyclovir in addition to current standard of care with temozolomide and radiotherapy.

A Phase 1b / 2 Open - label Dose Escalation Study of Entinostat in Combination With Pembrolizumab in Patients With Non-small Cell Lung Cancer With Expansion Cohorts in Patients With Non-small Cell Lung Cancer and Melanoma

Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double - blind, single - dose - escalation study.

It is also a two - part study with the first part being an open - label dose escalation study in at least 8 infants for 4 weeks to evaluate the safety profile of RG7916 and to determine the dose for Part 2.

The Phase 1 open - label, multicenter, dose escalation study of mRNA - 2416 is designed to determine the safety and tolerability of escalating iTu doses of mRNA - 2416 in patients with relapsed / refractory solid tumor malignancies or lymphoma, and define the maximum tolerated dose (MTD) and recommended dose for expansion (RDE) and schedule for iTu injections of mRNA - 2416.

The dose - escalation study has shown that higher doses of daratumumab alone can reduce both bone marrow plasma cells as well as paraprotein.

«We see real promise in therapeutic strategies for SMA that increase production of the SMN protein,» said Muscular Dystrophy Association Executive Vice President Research and Medical Director Valerie Cwik, M.D. «We're delighted ISIS Pharmaceuticals is moving forward with a Phase 1 dose - escalation study of its antisense drug in children with SMA.»

The Phase 1 study of ISIS - SMNRx is a single - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 14 who are medically stable.

The Phase I clinical trial of OMP - 54F28 (FZD8 - Fc) is an open - label dose escalation study in patients with advanced solid tumors for which there was no remaining standard curative therapy.

They opted for higher doses of pramlintide (240 ug TID [three times per day]-RRB- because in dose - escalation studies, the incidence and severity of adverse drug reactions was consistently low at all doses tested.

Not exact matches

A new study by Canadian tech innovator hub MaRS reported that tech companies in Toronto saw a significant escalation of...

The B.C. New Democrats» previous plan to restrict any additional bitumen flow by pipe or by rail while a new spill - safety study was ongoing — the plan that provoked Notley to temporarily ban B.C. wine — didn't seem to have been enough to provoke this escalation, or maybe it would?

A double - blind, placebo - controlled food challenge was conducted for other participants (with a total of 9.4 g of peanut protein administered in increments) in accordance with standard dose - escalation procedures25 (see the study protocol).

Further dose escalation and dose expansion studies are underway as well as translational tissue - based experiments to clarify the impact of this treatment combination.»

«Randomized trials have confirmed the value of radiation dose escalation for prostate tumors, and the potential benefits of larger radiation doses in fewer fractions, are expected to increase the therapeutic efficacy for men with prostate cancer,» said Anders Widmark, MD, a professor of radiation sciences at Umeå University in Umeå, Sweden and lead author of the study.

The study noted that the low intense negative deviant act of incivility is often the starting point of the escalation to more dangerous and violent behavior.

«This study shows that trauma care systems need to modify their conventional approach to activation to enable early recognition of these infants and swift escalation up to «major trauma patient» status in order to minimise delays to delivery of definitive care,» they write.

«Their slow visual system and the dynamic behaviour of the opponents during contests may reduce opportunities for visual assessment to the point where individual size - associated tendencies come to dominate decisions of persistence, escalation and retreat,» explain McGinley and Taylor in their study.

A study from Arnulf Grubler at Yale University in 2012 found that despite France's standardization of building nuclear from the 1970s through 2000s, the French nuclear program still saw substantial cost escalation.

• Few patients in either group were started on opioids or had escalations in their opioid dose during the study period;

The study looked at the escalation of obesity in terms of both exercise and caloric intake.

A Phase 1, First - in - Man, Multicenter, Open - Label, Two Part Dose - Escalation and Cohort Expansion Study of Single - Agent GBR 1342 in Subjects with Previously Treated Multiple Myeloma

A Phase 1/2, Open - Label, Dose - Escalation, Safety and Tolerability Study of INCB052793 in Subjects With Advanced Malignancies

ISIS - SMNRx is also being evaluated in an open - label, multiple - dose, dose - escalation Phase 2 study in infants with Type I SMA.

A Phase I / II, Open - label, Multi-center Study of the Safety and Efficacy of IMCgp100 using the Intra-patient Escalation Dosing Regimen in Patients with Advanced Uveal Melanoma

This study will use a 3 + 3 design for dose escalation (Part 1), followed by an expansion cohort (Part 2) at the recommended phase 2 dose level.

More than 75 percent of patients had completed the dose escalation when study data were analyzed.

Rather than calculating a standard dose of hydroxyurea based on patients» weight, researchers used a dose - escalation approach to determine the maximum tolerated dose for each of the 230 St. Jude patients enrolled in the study.

A Preliminary Prospective Study of an Escalation in «Maximum Daily Drinks», Fronto - Parietal Circuitry and Impulsivity - Related Domains in Young Adult Drinkers

Therapy escalation in patients with inflammatory bowel disease following clostridium difficile infection is not associated with adverse clinical outcomes: An ibd remedy study [Meeting Abstract]

Back in March, Steven Spielberg's next project was announced: The Post, a drama about the real - life controversy surrounding The Washington Post's decision to publish the Pentagon Papers in 1971, a study that indicted the U.S. for its involvement in the escalation and continuation of the Vietnam War.

Washington — The sharp escalation of college - tuition costs throughout the 1980s occurred in part because many institutions, faced with a decline in the size of their traditional market, chose «to compete not through lower prices but through expanded and improved facilities and services,» a study released here last week suggests.

The escalation of conflict in Syria may also provide a case study in geopolitical driven volatility in the short - run that is outweighed by stronger market fundamentals over the course of the year.

Doug Harvey in the LA Weekly: «One of the most pronounced symptoms of the wide - scale institutionalization of artistic practice has been the rise of curatorial studies as an academic category and the subsequent escalation of the curator's role and visibility — sometimes to the point of supplanting the place of the artist as the raison d'être of an exhibition.

The following example of a work history section for an account manager can help.Account Manager, Sterling Media Management, Tucson, AZ — 3/2011 — present • Resolved client issues to avoid escalation • Created and managed schedule of marketing campaign releases • Increased profitability of 10 major client accounts within two quarters • Scheduled and coordinated client shows and exhibitionsAccount Manager, First Response LLC, Tacoma, WA — 7/2004 -5 / 2009 • Prepared media release schedules for over 50 clients • Analyzed public relations case studies and integrated emerging best practices • Trained and led sales teams to exceed quotas • Received recognition as top performer in division for the last four quarters

Customer Service Representative — Duties & Responsibilities Oversee customer service and IT support across a variety of industries and settings Responsible for 24 hour, 7 days per week help desk management for both clients and team members Utilize interpersonal skills and advanced IT knowledge in service of national and international clients Direct team of IT and customer service professional handling inquiries and escalations in a timely manner Responsible for Level 1, 2, and 3 service across a variety of highly technical IT matters Document customer service activities, update client accounts, and follow up as needed Build and strengthen professional relationships with clients and partners resulting in loyalty and strong revenue Responsible for departmental budget, team workflows, and IT inventory management Hire and train employees in customer service and IT management best practices Manage varied IT projects including migrations, infrastructure development, and network administration Utilize strong abilities and training in Microsoft, Linux, and Apple systems Serve as liaison between multiple departments and senior leadership Encourage high customer retention by maintaining friendly, supportive contact with existing clients Study internal literature to become an expert on products and services Represent company brand with poise, integrity, and positivity

Future studies could further test this potential transactionality by not only regarding peer problems as risk factors for the escalation of depressive symptoms, but also as consequences of internalizing problems.

In the current study, we extend this prior work by examining whether the interaction between internalizing and externalizing symptoms in early adolescence predict escalation of alcohol and marijuana use during adolescence into young adulthood.

In sum, the first objective of the present study was to investigate whether clique isolation is a social risk factor for an escalation in depressive symptoms in early adolescence.