Sentences with phrase «essential gene for»

We identify METTL3 as an essential gene for growth of acute myeloid leukaemia cells in two distinct genetic screens.

Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene for embryonic stem cells, also regulates cell division in stratified epithelia — those that form part of the epidermis of the skin or cover the esophagus or the vagina — in adult organisms.

The results of our microRNA (miRNA) profile analysis for these cells revealed that CSCs that are highly metastatic to bone and brain expressed significantly lower level of miR - 7 and that this miRNA was capable of modulating one of the essential genes for induced pluripotent stem cell, KLF4.

Not exact matches

The worry is that «the technical ability to disaggregate and recombine genetic, gestational and rearing connections and to control the genes of offspring may... undermine essential protections for offspring, couples, family and society.»

Because the genes that are massively amplified in the neochromosomes are essential for the cell's survival, drugs that turn those off are an obvious target for research.

The Hawaiian strain changed that thinking: «How is this wild isolate alive and happy without a gene that's supposed to be essential for development?»

A virus containing the gene that codes for two molecular «switches» essential for turning skin cells into brown fat was used to trigger the change (Nature, DOI: 10.1038 / nature08262).

The huntingtin gene is essential for embryonic development, and scientists have already shown that if mouse embryos don't have it at conception, they die in utero.

They studied KAP1, a gene that codes for an essential protein associated with several fundamental processes in neurodevelopment.

These genes date back to the early origin of life on the planet, and they're so essential that their text has been preserved for more than 3 billion years.

He essentially re-created Keeler's blind mice by shutting down genes essential for the development of rods and cones while still exposing his subjects to cycles of light and dark.

A new study indicates an essential role for a maternally inherited gene in embryonic development.

Last January, state - of - the - art computer aided modeling enabled the researchers to identify an anti-cancer agent capable of deactivating a gene known to be essential for the metastatic spread of breast cancer.

«We've sequenced everything on this planet, and we still don't know 149 genes that are most essential for life!»

This gene helps makes collagen, the protein that forms bone matrix and is essential for bone growth.

The actin gene encodes a structural protein that is essential for cell integrity.

Knocking down expression with RNA interference showed that 30 % of newly arisen genes are essential for viability.

In 2001 a team of British scientists announced the discovery of a gene, called FOXP2, that seems to be essential for language.

«However, recent work has shown that at least some of the fungal partners in arbuscular mycorrhizal symbioses lack the genes for enzymes involved in the major pathway of lipid biosynthesis, and are therefore unable to produce certain essential fatty acids,» Gutjahr explains.

Most DNA research focuses on genes that contain encrypted messages for making proteins, the cellular workhorses essential to life.

When a gene is up for grabs, speed is essential because the basic techniques of discovery are open to every laboratory.

These genes are believed to be essential for the normal function of nerve cells, and previous studies have linked these mutations to problems with synaptic function — how neurons communicate with each other.

Computer aided modeling of how the Bcl3 gene functions inside the cell allowed the group to identify a pocket on the surface of Bcl3 essential for its function.

«Microsatellite length and location appears to be essential for EWS / FLI to activate the oncogenic gene targets,» says Dr. Lessnick.

«Identifying targets essential to cell survival in tumor suppressor genes has long been an investigational goal with the aim of offering cancer - specific vulnerabilities for targeted therapy,» said Ronald DePinho, M.D., professor of Cancer Biology, MD Anderson president, and senior author for the Nature paper.

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

«We reasoned that this retained synthetic essential gene might be required for cancer - promoting actions when the cancers lose specific tumor suppressor genes.»

Clearly, when the gene came from a father — and only then — it was essential for growth.

The disease arises from a mutation in genes that normally make a protein, called myotubularin, essential for proper muscle function.

To kill an insect, the RNAs must silence a gene essential for life, and species often share genes of such crucial importance, making it difficult to target one insect over another.

Because the precise activation of Hox genes is essential for a cell's fate, «the research should prove extremely useful in developing novel embryonic stem cell - based therapies, Mazzoni adds.

Scientists at NYU Langone Medical Center and New York University have demonstrated that a specialized DNA - binding protein called CTCF is essential for the precise expression of genes that control the body plan of a developing embryo.

«They need to find another gene in the insect that is essential for it but not in other organisms,» says Saskia Hogenhout of the John Innes Centre in Norwich, UK.

One of these genes encodes the receptor for folic acid, which is an essential B vitamin necessary for normal growth and development.

But Ziv Bar - Joseph, an associate professor in the Machine Learning Department and the Lane Center for Computational Biology, said that view of what is essential and what isn't reflects how scientists study genes — by noting their effects on an organism when a gene is removed — not necessarily the gene's importance.

Rhythmic expression of key genes is essential for maintaining proper timekeeping of the body's clock.

Named HCR1, this gene reduces water entry into the roots when there's a lack of oxygen, but only when the soil is also rich in potassium, a mineral salt essential for plant growth.

Recently, scientists learned that microRNA genes can control this essential process by coding for a microRNA strip that binds to the messenger RNA, effectively turning off production of the protein.

Geneticists say large population databases will be essential to pin down what portion of people carrying potentially harmful mutations will develop disease, and if the effects can be mitigated by other genes, for example.

This interaction is explained by divergent evolution occurring among paralogs of an essential duplicate gene, for which the functional copy is not located at the same locus in different accessions.

Dr. Valerie Brid O'Leary and colleagues show that epigenetic DNA methylation is increased through the radiation - induced activation of MAT2A, a gene responsible for providing the S - Adenosyl Methionine essential for the methylation reaction.

When flying isn't essential for survival, the mutations that hinder flight can gradually accumulate in the gene pool.

Because CRISPR will never fully be rid of off - target effects, the key question for a given therapy is not strictly how many unwanted cuts it makes, but whether it disrupts any essential genes, says Jiing - Kuan Yee, a molecular biologist at the research center City of Hope in Duarte, California.

Since proper functioning of the fat body is essential for the development of the female reproductive system after a blood meal, identifying which miRNAs are important to fat body functions, and what specific genes they target, can help design ways to manipulate the levels of microRNA or their targets, affect their interactions, disrupt mosquito reproduction, and thus prevent the spread of diseases the mosquitoes transmit.

They also identified genes necessary for the production of sucrose, which turn out to be also essential for nectar secretion.

Next steps include trying to duplicate the mutant of this gene in the pathogenic form of mycobacteria, to demonstrate that the gene is indeed essential as predicted for infection to take place, the microbiologists say.

For any given cell or tissue sample, these arrays can probe for the genes essential for understanding the underlying state of wellness or diseaFor any given cell or tissue sample, these arrays can probe for the genes essential for understanding the underlying state of wellness or diseafor the genes essential for understanding the underlying state of wellness or diseafor understanding the underlying state of wellness or disease.

Animals need these as essential nutrients for a wide range of basic bodily chores, such as gene regulation, cell signaling and amino acid breakdown.

Dr Rollins, from Deakin's Centre for Integrative Ecology, within the School of Life and Environmental Sciences, said mitochondria were essential for sustaining life and had their own set of genes, usually only inherited from the mother.