Sentences with phrase «essential gene known»

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

Not exact matches

Last January, state - of - the - art computer aided modeling enabled the researchers to identify an anti-cancer agent capable of deactivating a gene known to be essential for the metastatic spread of breast cancer.

«We've sequenced everything on this planet, and we still don't know 149 genes that are most essential for life!»

If the altered genome wasn't viable, they knew they had cut out an essential gene that had to be restored.

Finally, what researchers really want to know is what specific part of each gene is essential.

The researchers utilized a technique known as exon skipping, a form of RNA splicing, to eliminate the portion of one of the IgE receptor gene's mRNA that is essential to making a protein which places the IgE receptor on the mast cell surface.

SOX2 continues to be expressed in the inner ears of mice lacking Math1 (also known as Atoh1 and HATH1), a gene essential for hair cell differentiation, whereas Math1 expression is absent in Lcc mutants, suggesting that Sox2 acts upstream of Math1.

In addition we found the first human genes essential for host - pathogen interactions where few details are known, as is the case for cytolethal distending toxin secreted by certain strains of E. coli.

«This new genomic platform would allow us to quickly engineer any essential gene in the «simplest» M. mycoides genome and obtain a quick, binary «yes» or «no» answer as to whether the modification introduced could support cellular viability.

Using this high - throughput approach, we defined three sets of chromosomal non-essential genes essential for growth during exposure to colistin (n = 35), imipenem (n = 1) or ciprofloxacin (n = 1) in addition to known resistance determinants, collectively termed the «secondary resistome».

While folic acid is generally considered essential for anyone that's trying to conceive or already pregnant, a common genetic disorder known as the MTHFR gene mutation can mean that folic acid can potentially be harmful to both you and your baby.

Studies suggest that homozygous defects on this gene leaves excess copper in the extracellular matrix where, through a process known as the Fenton reaction, excess free radicals are generated which possibly damage cells and gobble up essential nutrients like selenium and zinc.