Sentences with phrase «essential genes in»

We designed our strategy to select against re-targeting the «knockout - first» allele and identify essential genes in ES cells, including the histone methyltransferase Setdb1.

We use the Haplobank in reverse genetic screens to investigate the temporal resolution of essential genes in mES cells, and to identify novel genes that control sprouting angiogenesis and lineage specification of blood vessels.

In a breakthrough study, Blomen et al. (Science, 2015) used extensive mutagenesis to describe the complete set of essential genes in the human haploid cell line Hap1.

Even so, Goldstein is quick to point out that 3230 is not the complete set of essential genes in the human body and that only by studying more exomes will researchers be able to refine that number.

Ping and others have similarly found such essential genes in bacteria or in mice.

«By using chloroplast transformation we generated potato plants that accumulate high amounts of long stable dsRNAs targeting essential genes in the beetle,» says Ralph Bock.

«This new genomic platform would allow us to quickly engineer any essential gene in the «simplest» M. mycoides genome and obtain a quick, binary «yes» or «no» answer as to whether the modification introduced could support cellular viability.

Not exact matches

Genetic Variants of the FADS1 FADS2 Gene Cluster Are Associated with Altered (n - 6) and (n - 3) Essential Fatty Acids in Plasma and Erythrocyte Phospholipids in Women during Pregnancy and in Breast Milk during Lactation

Because the genes that are massively amplified in the neochromosomes are essential for the cell's survival, drugs that turn those off are an obvious target for research.

The huntingtin gene is essential for embryonic development, and scientists have already shown that if mouse embryos don't have it at conception, they die in utero.

And scientists have isolated some of the essential genes that allow bacteria to tolerate their harsh living conditions — because these same genes might help in the creation of new vaccines.

They studied KAP1, a gene that codes for an essential protein associated with several fundamental processes in neurodevelopment.

A new study indicates an essential role for a maternally inherited gene in embryonic development.

Functioning with 473 genes, the cell is a milestone in his team's 20 - year quest to reduce life to its bare essentials and, by extension, to design life from scratch.

In this way, the team identified a new small protein, growth inhibitor gene product (Gp) 0.6, which specifically targets and inhibits the activity of a protein essential to bacterial cells.

In 2001 a team of British scientists announced the discovery of a gene, called FOXP2, that seems to be essential for language.

«However, recent work has shown that at least some of the fungal partners in arbuscular mycorrhizal symbioses lack the genes for enzymes involved in the major pathway of lipid biosynthesis, and are therefore unable to produce certain essential fatty acids,» Gutjahr explains.

The proportion of genes that are essential is similar in every evolutionary age group that we examined.

Under constitutive silencing of these young essential genes, lethality was high in the pupal stage and also found in the larval stages.

These data suggest that new genes frequently and rapidly evolve essential functions and participate in development.

Based on studies of other tissues, the genes very well could play an essential role in the health of the corneal endothelium, according to the study authors.

With just a bit of hindbrain and a flap of ear where the head should be, the mouse pup is a freak of science — but it is also the first proof that a single gene plays an essential role in creating a head.

«Identifying targets essential to cell survival in tumor suppressor genes has long been an investigational goal with the aim of offering cancer - specific vulnerabilities for targeted therapy,» said Ronald DePinho, M.D., professor of Cancer Biology, MD Anderson president, and senior author for the Nature paper.

By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

The disease arises from a mutation in genes that normally make a protein, called myotubularin, essential for proper muscle function.

Explaining the background to the research, Dr. Ramiro describes how «an essential process in antibody generation takes place in structures called germinal centers, where antibody genes undergo small modifications that increase the efficiency and specificity of the immune response.

GENES from ancient viruses may be an essential component of mammalian reproduction, helping the placenta to establish itself in the womb, suggest biologists in California.

The protein studied in the mold is part of a larger family of proteins also found in humans and involved in many essential biological processes including gene regulation and fatty acid metabolism.

Because the precise activation of Hox genes is essential for a cell's fate, «the research should prove extremely useful in developing novel embryonic stem cell - based therapies, Mazzoni adds.

«They need to find another gene in the insect that is essential for it but not in other organisms,» says Saskia Hogenhout of the John Innes Centre in Norwich, UK.

Stewart and other researchers would like to compare primitive genes and proteins with modern ones, in order to sort out which molecular structures are essential to life, and which are passed down through the ages as «frozen accidents».

Genes that displayed no variants should be essential or play crucial biological functions,» says Ping Xu, a molecular microbiologist at Virginia Commonwealth University in Richmond.

«The cell did not evolve to protect itself against the deletion of these «essential» genes,» Bar - Joseph said, noting that's an event that doesn't often occur in nature.

But Ziv Bar - Joseph, an associate professor in the Machine Learning Department and the Lane Center for Computational Biology, said that view of what is essential and what isn't reflects how scientists study genes — by noting their effects on an organism when a gene is removed — not necessarily the gene's importance.

Instead there is an essential smoothness in the way organisms are related to their genes: A small change in DNA yields a small change in a creature — not always, but often enough that gradual evolution is possible.

Cloning is frequently employed to amplify DNA fragments containing genes, an essential step in their subsequent analysis.

Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene for embryonic stem cells, also regulates cell division in stratified epithelia — those that form part of the epidermis of the skin or cover the esophagus or the vagina — in adult organisms.

Named HCR1, this gene reduces water entry into the roots when there's a lack of oxygen, but only when the soil is also rich in potassium, a mineral salt essential for plant growth.

A large number of rare childhood diseases stem from mutations in genes that play an essential role in lipid synthesis.

PRC2 is essential to gene regulation and expression in all multicellular organisms.

This interaction is explained by divergent evolution occurring among paralogs of an essential duplicate gene, for which the functional copy is not located at the same locus in different accessions.

When flying isn't essential for survival, the mutations that hinder flight can gradually accumulate in the gene pool.

A new study involving roundworms appears to have isolated one gene — a transcriptional factor (or gene that controls the regulation of other genes in the genome)-- that appears to be an essential member of the pathway that translates reduced caloric intake into a longer life span.

Because CRISPR will never fully be rid of off - target effects, the key question for a given therapy is not strictly how many unwanted cuts it makes, but whether it disrupts any essential genes, says Jiing - Kuan Yee, a molecular biologist at the research center City of Hope in Duarte, California.

The therapy consists in injecting into the hippocampus - a region of the brain essential to memory processing - a gene which causes the production of a protein blocked in patients with Alzheimer's, the «Crtc1» (CREB regulated transcription coactivator - 1).

Next steps include trying to duplicate the mutant of this gene in the pathogenic form of mycobacteria, to demonstrate that the gene is indeed essential as predicted for infection to take place, the microbiologists say.

«Mutations in gene essential for cell regulation cause kidney cancer in children.»

The GJB6 gene encodes the CONNEXIN 30 protein, which is essential in hearing development, and a deficiency of the gene results in the second most common disease among cases of hereditary hearing loss that have no other disease in the inner ear.

The Bag1 gene, for example, codes for a protein that in humans is involved in inhibiting an essential natural process called «programmed cell death.»