Not exact matches
«Identifying targets
essential to
cell survival
in tumor suppressor
genes has long been an investigational goal with the aim of offering
cancer - specific vulnerabilities for targeted therapy,» said Ronald DePinho, M.D., professor of Cancer Biology, MD Anderson president, and senior author for the Nature
cancer - specific vulnerabilities for targeted therapy,» said Ronald DePinho, M.D., professor of
Cancer Biology, MD Anderson president, and senior author for the Nature
Cancer Biology, MD Anderson president, and senior author for the Nature paper.
Scientists from the Spanish National
Cancer Research Centre (CNIO) have discovered that NANOG, an
essential gene for embryonic stem
cells, also regulates
cell division
in stratified epithelia — those that form part of the epidermis of the skin or cover the esophagus or the vagina —
in adult organisms.
«Mutations
in gene essential for
cell regulation cause kidney
cancer in children.»
However, such CRISPR screens are sensitive to a phenomenon called the copy number effect, where
genes that have been repeatedly duplicated within a
cell (as commonly happens
in cancer cells) can be flagged as
essential regardless of whether they are or not.
* Acute promyelocytic leukaemia is caused by the modification of two
genes, RAR and PML, leading to the development of
cancer cells; ** the
gene coding for p53 protein plays an
essential role
in cell proliferation under normal conditions and
in maintaining the integrity of the
cell genome.