Even so, Goldstein is quick to point out that 3230 is not the complete set of
essential genes in the human body and that only by studying more exomes will researchers be able to refine that number.
In a breakthrough study, Blomen et al. (Science, 2015) used extensive mutagenesis to describe the complete set of
essential genes in the human haploid cell line Hap1.
Not exact matches
The protein studied
in the mold is part of a larger family of proteins also found
in humans and involved
in many
essential biological processes including
gene regulation and fatty acid metabolism.
The Bag1
gene, for example, codes for a protein that
in humans is involved
in inhibiting an
essential natural process called «programmed cell death.»
If DNA is a jungle, then the viruses are the animals and plants that live and adapt within it, says Villarreal, who
in 2001 showed that the presence of a viral
gene is
essential for the formation of the
human placenta.
But
human leukocyte antigens — a group of
genes that encode proteins
essential to the
human immune system —
in the samples showed that a few individuals had a type, or allele, found among only Native Americans.
A region of the
gene that produces the PACAP38 protein has held nearly constant, even
in humans, presumably because the protein plays diverse roles
in neuron communication and is
essential for normal development of the cerebellum, affecting brain cell migration, for example.
For
gene editing to work, it is
essential to uniquely target a single site among the 3 billion nucleotides
in the haploid (single set of unpaired chromosomes)
human genome.
In addition we found the first
human genes essential for host - pathogen interactions where few details are known, as is the case for cytolethal distending toxin secreted by certain strains of E. coli.
Laddha SV, Ganesan S, Chan CS, White E. Mutational landscape of the
essential autophagy
gene BECN1
in human cancers.
Within the
essential immune loci of the major histocompatibility complex, we find HLA - B to be the most polymorphic
gene on chromosome 6 and
in the
human genome.