Sentences with phrase «essential subunits»

In contrast, transcription of constitutive genes encoding essential subunits of complexes is not coordinated because of stochastic fluctuations.

Presenilin - 1 (PS1) or presenilin - 2 (PS2), nicastrin (NCT), anterior pharynx - defective 1 (Aph - 1), and presenilin enhancer - 2 (Pen - 2) have been considered the minimal essential subunits required to form an active γ - secretase complex.

We have tested this hypothesis by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N - methyl - d - aspartate (NMDA) receptor NR1, specifically in dentate gyrus granule cells.

Not exact matches

Cognate transfer RNA (tRNA) binding induces global domain movements of the 30S subunit and changes in the conformation of the universally conserved and essential bases A1492, A1493, and G530 of 16S RNA.

The envelope consists of three gp120 and gp41 proteins positioned close together, and referred to as «trimers,» that open up like a flower in the presence of CD4, exposing the gp41 subunit that is essential for subsequent aspects of the mechanism that causes infection.

XPD encodes one of the two helicase components of basal transcription / DNA repair factor IIH (TFIIH), a ten - subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via the nucleotide excision repair (NER) pathway [6,7].

Therefore, Teitell's group opted to further modify their constructs with a 3 ′ - UTR mitochondrial targeting sequence (MTS) from human mitochondrial ribosomal protein S12 — the same essential approach used to optimize the import of allotopically - expressed proteins by Dr. Marisol Corral - Debrinski, (3,4) and subsequently advanced for multiple additional ETS subunit proteins by Dr. Matthew O'Connor's group at the SENS Foundation Research Center (RC).

Pol III is pretty complicated — it is made up of 17 different subunits encoded by 17 different essential genes.

The p127 Subunit (DDB1) of the UV - DNA Damage Repair Binding Protein Is Essential for the Targeted Degradation of STAT1 by the V Protein of the Paramyxovirus Simian Virus 5

This little - heralded, meticulous investigation into the effects of ablation of the telomerase catalytic subunit in mice with human - like telomeres provides us with strong reassurance that, should it prove to be the preferred approach for implementing the OncoSENS strategy, the effects of knocking out TERT would be limited to those dictated by the loss of telomere - lengthening per se, and would not lead to an unintentional loss of some essential but hitherto - unknown phsyiological function.

The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF - 1.

RH5 is a leading subunit vaccine candidate because anti-RH5 antibodies inhibit parasite growth and the interaction with its erythrocyte receptor basigin is essential for invasion.

The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion.