Sentences with phrase «established as a tumor»

Not exact matches

Seven to eight weeks after the tumor was established, each mouse received one intravenous injection of GD2 CAR - T cells or, as a control treatment, an injection of CAR - T cells that react to a different target.

«As a cancer immunotherapist, what gets me really excited is when you take an established tumor and you make it disappear,» said Crystal Mackall, MD, professor of pediatrics and of medicine and the study's other senior author.

Researchers are already using single - cell analysis to identify genetic variations within tumors and tissues, and Langsdorff says the technique is quickly establishing a foothold in microbiology as well.

«The recent discovery of tumor - promoting milieus, referred to as metastatic niches, that are established at distant sites prior to or upon the arrival of disseminated tumor cells could explain cancer cells that relapse early, but in late relapsing populations, what tumor cells do from the time of dissemination to the time they become clinically detectable has been a big question.»

Until now, scientists have failed to establish a link between the properties of pancreatic cancer, such as its aggressiveness, and changes, i.e. mutations, in the tumor's genome.

When the cell line was established in the 1960s, material from the original tumor was saved as thin sections on microscope slides.

As famously chronicled in science writer Rebecca Skloot's best - selling book, the cell line was established, without Lacks's consent, from a cervical tumor that she was diagnosed with in 1951.

The authors studied a standard panel of 60 established human tumor cell lines representing nine different human cancers, as well as several specimens of human primary ovarian cancer.

Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors.

Due to the high efficiency of establishing organoid models from different tissues and diseases, such as cancer, organoid technology allows the generation of large living biobanks of tumor organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell line and xenograft - based drug studies (7,19).

NCI is establishing a national database to house and integrate genomic information from tumors with clinical response data (e.g., tumor shrinkage) and outcomes information (e.g., length of survival) as a resource for scientists, health care professionals, and patients.

Just as adults might not stay healthy if they only ate liquid baby formula, new tumors have a different set of requirements than more mature, established cancers to thrive and spread.

Background In our institute, the first research program on disseminated tumor cells (DTC) detection in the bone marrow of early breast cancer patients was initiated in the late 90's; with about a thousand patients included, we constituted one of the largest cohort ever reported and contributed to the landmark report that established bone marrow DTC as a level - of - evidence 1 prognostic factor in early breast cancer (Braun, N Engl J Med 2005).

This study design will establish whether (1) DAXX can serve as a marker for early tumor growth or later advanced / metastatic PCa, and (2) high DAXX expression associates with indolent versus lethal PCa.

In addition to DAXX, immunohistochemistry studies will include DAPK1 and DAPK3 so as to establish a relationship between DAXX and the DAPK1 / 3 tumor suppressors.

The VHL - HIF - 1 axis is of great interest overall, as cancer cells often reside in a low - oxygen milieu and upregulate HIF to establish a glycolytic state favoring tumor cell survival.

Although the differing effects of hypoxia reported here are in conflict with previously published data, where no contrasting effect was seen (18 — 20), our data was produced using 13 primary breast cancer samples, as well as established cell lines, and the opposing effects in hormone receptor — positive and negative tumors, measured using multiple in vitro and in vivo CSC assays, were consistent in all cases.

Soy Protein isolate is established as harmful since is does indeed raise insulin like growth factor quite significantly which accelerates aging and promotes tumor growth.

Given the well - established role of steroid hormones in breast cancer etiology for postmenopausal women, these findings may have important health implications» Tumor growth from these hormone imbalances is also evident «A dramatic increase in estrogen - dependent malignant diseases, such as ovarian, corpus uteri, breast, testicular and prostate cancers has been recognized.

As part of our mission to improve the health and longevity of our Berners, the Berner - Garde Foundation (BGF) and Michigan State University (MSU), with support from the Bernese Mountain Dog Club of America (BMDCA), have established a Repository that collects, stores and maintains DNA and tumor tissue samples from Bernese Mountain Dogs.