Sentences with phrase «established cell model»

This is a breast cancer stem cell line 1 (BCSC1) from the newly established cell model.

Not exact matches

As I stated in my original article, prior to conducting experiments with human cells, ANT - OAR techniques would need to be rigorously tested in animal models to establish a procedure that guarantees with reasonable certainty that an embryo is not generated.

Before we established in - house human taste cell (HTC) technologies, it was not possible to use human tongue - derived cells as a model, due to the lack of homogenous, proliferating cell lines with defined properties, which is a prerequisite to establish comprehensive research and screening programs.

As well as allowing the use of stem cells grown from established cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organs.

Guo and his collaborators continue their studies by establishing additional mouse models of leukemia that have been transplanted with patient cells of relapsed and refractory disease.

Now, the researchers have discovered an alternative in a mouse model: in the case of breast tumours with a specific defect in DNA repair, the animals can be cured using already established, cheap chemotherapy drugs, if enough DNA damage can be inflicted on the resting tumour cells.

Scientists of Helmholtz Zentrum Muenchen have now established a model for latent HIV infection of brain cells.

«The novelty of this study is two-fold: We used a preclinical prevention paradigm of a CRF - antagonist (a drug that blocks the CRF receptor in brain cells) called R121919 in a well - established AD model — and we did so in a way that draws upon our experience in human trials.

Professor Fiona Watt, Director of the Centre for Stem Cells and Regenerative Medicine, said: «We are excited by our findings as they establish a clear link between cancer susceptibility and an allergic skin condition in our experimental model.

When using a well established model of colorectal cancer, the researchers observed that dietary emulsifier consumption was sufficient to make the animals more susceptible to developing colonic tumors because this created and maintained a pro-inflammatory environment associated with an altered proliferation / apoptosis (cell death) balance.

Our experts in mucosal vaccine delivery have established in vitro and in vivo models to assess the activity of adjuvants and vaccine formulations on innate and adaptive immune cells, as well their capacity to stimulate different effector mechanisms of clearance.

Establish infrastructure to test repurposed drugs in cell culture and animal models for potency, pharmacokinetic (PK), and pharmacodynamic (PD) studies.

A new study establishes that the injection of a collagen - based biomaterial can mobilize endogenous stem cells to promote kidney regeneration in a mouse model

We then establish a quantitative «constant - kink - saturation» relation between χaa and the fill factor in organic solar cells that is verified in detail in a model system and delineated across numerous high - and low - performing materials systems, including fullerene and non-fullerene acceptors.

Due to the high efficiency of establishing organoid models from different tissues and diseases, such as cancer, organoid technology allows the generation of large living biobanks of tumor organoids that are amenable for middle - throughput drug screens and may allow personalized therapy design, as a complement to cell line and xenograft - based drug studies (7,19).

In close collaboration with Dr. Yamanaka Dr. Conklin's laboratory was able to establish new iPS cell disease models, gain new insights into iPS cell biology, and develop new tissue engineering methods.

In the classical model of tumor dissemination, specialized cells at the invasive front undergo epithelial - mesenchymal transition (EMT) and enter peripheral tumor - coalescing blood vessels to establish metastatic lesions by extravasation of CTCs.

For a decade, LJI's Toshiaki Kawakami, M.D., PhD., has defined mast cell signaling that either worsens or ameliorates eczema, relying heavily on animal models of atopic dermatitis that he established.

The arrival of several teams has diversified pathological indications in the context of two major research established at the outset, cell therapy and disease modeling paving the way for drug screening.

Ultimately, we use all this information to establish innovative culture techniques for generating unlimited neural stem cell sources for the derivation of specific types of clinically relevant neuronal or glial cells, for their use in disease modelling and drug discovery platforms, and towards refining their efficacy for future cell replacement - based therapy.

Working with Dr. Weiskopf, we established a model of human dengue disease using HLA transgenic mouse strains, and characterized human dengue - specific CD8 + and CD4 + T - cell responses in natural infection as well as following vaccination.

Many investigators, including those at Emory, are using the technology to establish â $ œdisease in a dishâ $ models and derive iPS cells from patient donations, turning them into tools for personalized medicine research.

Having established the importance of the miR - 181a target genes, Smad1 and Smad5, in BMP / GDF ligand - induced neurite growth, we next determined whether miR - 181a - modulated Smad phosphorylation / activation and neurite growth in SH - SY5Y cells, which are a widely used cell line model of human mDA neurons which also express the miR - 181a targets, BMPR2 and Smad1 / 5 [18,38].

«The model will help scientists identify new approaches to design and establish cell culture models for other human cells that previously had resisted viable culture conditions,» said Ozdener

To investigate whether miR - 181a plays a role in these effects, we transfected SH - SY5Y cells, which are a well - established model of human mDA neurons [18,38], with an miR - 181a inhibitor / antagomir.

The authors highlight the successful application of both induced pluripotent stem cells and embryonic stem cells for this first example of the in vitro formation of functional and mature skeletal muscle tissue, thereby also establishing the potential for patient - specificity in disease modeling, drug development, and possible muscle repair.

Our study outlines the major sources of genetic and phenotypic variation in iPS cells and establishes their suitability as models of complex human traits and cancer.

The advent of human - induced pluripotent stem cell (hiPSC) technology has provided a unique opportunity to establish cellular models of disease from individual patients, and to study the effects of the underlying genetic aberrations upon multiple different cell types, many of which would not normally be accessible.

Established a Jurkat cell model of HIV latency (5A8 cells) that is inducible by T - cell receptor cross-linking and displays drug reactivation profiles resembling that from resting CD4 T cells from aviremic patients.

To demonstrate Amrose functionality in an established higher model system, Amrose v0 — v4 variants were cloned into the pCS2 + vector system to synthesize mRNA by in vitro transcription, which was used for injection into one - cell stage zebrafish embryos.

The problems would surely stem from console manufacturers who can make profitable growth once their machine is established (see Nintendo) and a universal medium for any competitive industry isn't exactly hard, it's almost impossible as clearly seen in the cell phone market with various software formats and even battery adapters varying from model to model.