Sentences with phrase «establishes human model»

Not exact matches

As I stated in my original article, prior to conducting experiments with human cells, ANT - OAR techniques would need to be rigorously tested in animal models to establish a procedure that guarantees with reasonable certainty that an embryo is not generated.

This glowingly successful model can be expanded further to establish predictions about the future evolution of humans and human social systems.

Before we established in - house human taste cell (HTC) technologies, it was not possible to use human tongue - derived cells as a model, due to the lack of homogenous, proliferating cell lines with defined properties, which is a prerequisite to establish comprehensive research and screening programs.

The Danish Institute for Human Rights (DIHR) is an independent National Human Rights Institution established by an act of Danish Parliament in 1987 and modeled in accordance with the UN Paris Principles.

As well as allowing the use of stem cells grown from established cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organs.

That liberals are just as guilty of antiscience bias comports more with accounts of humans chomping canines, and yet those on the left are just as skeptical of well - established science when findings clash with their political ideologies, such as with GMOs, nuclear power, genetic engineering and evolutionary psychology — skepticism of the last I call «cognitive creationism» for its endorsement of a blank - slate model of the mind in which natural selection operated on humans only from the neck down.

This is why it is important to study a very well established host - virus system like myxoma virus in the European rabbit as a model for human viruses and why understanding this mutation is important.»

With that in mind, the Penn Vet team chose to examine two of their well - established canine models of RP, which recapitulate many features of the human diseases, each involving mutations in different genes.

Coming from a human resources perspective (I previously worked for 3 years in the university's employment office), it seemed natural to me to develop an administrative model for the office that was similar to the staff hiring model: First, develop a detailed database to track postdocs; second, establish a postdoctoral appointment process; and third, develop resources for postdocs, faculty, and staff (including establishing minimal goals for programming and developing a Web site).

Dr Kristensen recommends that an inter-disciplinary approach be taken to address this, «by combining epidemiological data from human studies with more experimental research on models, such as rodents, it may be possible to firmly establish this link and determine how it happens, so that pregnant women in pain can be successfully treated, without risk to their unborn children.»

«The novelty of this study is two-fold: We used a preclinical prevention paradigm of a CRF - antagonist (a drug that blocks the CRF receptor in brain cells) called R121919 in a well - established AD model — and we did so in a way that draws upon our experience in human trials.

These three personality traits are part of the five - factor personality model, a well - established framework used to theoretically understand the human personality.

«We already established an infection model for the human lung.

Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging.

In the first part, they established the mouse model that mimics multiparity - induced obesity in humans.

In 2009, he established the Center for Human Disease Modeling at Duke University, which aims to facilitate collaboration across disciplines and to develop physiologically relevant, scalable tools to study variation among human patient genHuman Disease Modeling at Duke University, which aims to facilitate collaboration across disciplines and to develop physiologically relevant, scalable tools to study variation among human patient genhuman patient genomes.

Brain research is already considered high priority is many countries as evidenced by recently established national and regional programs: 1) The EU - funded Human Brain Project, established in 2013, overarches neuroscience and ICT, with the aim to model human brain, better understand brain disorders, and develop new therapies and technoloHuman Brain Project, established in 2013, overarches neuroscience and ICT, with the aim to model human brain, better understand brain disorders, and develop new therapies and technolohuman brain, better understand brain disorders, and develop new therapies and technologies.

Since 2006 when Biomedcode was established, we have evaluated hundreds of therapeutics including novel biologics, biosimilars, biobetters and small molecules using a unique array of animal disease models closely mimicking the complexity of human inflammatory conditions.

Working with Dr. Weiskopf, we established a model of human dengue disease using HLA transgenic mouse strains, and characterized human dengue - specific CD8 + and CD4 + T - cell responses in natural infection as well as following vaccination.

We have established a technique to generate syngeneic murine metastatic breast cancer model that mimic human breast cancer progression (Rashid OM et al, Breast Cancer Research and Treatment 2014).

WFSM establishes laboratory to develop transgenic and knockout mice to model human disease and shed light on function of human genes.

This project will adapt well - established perceptual and cognitive paradigms from human studies to mouse models.

Having established the importance of the miR - 181a target genes, Smad1 and Smad5, in BMP / GDF ligand - induced neurite growth, we next determined whether miR - 181a - modulated Smad phosphorylation / activation and neurite growth in SH - SY5Y cells, which are a widely used cell line model of human mDA neurons which also express the miR - 181a targets, BMPR2 and Smad1 / 5 [18,38].

«The model will help scientists identify new approaches to design and establish cell culture models for other human cells that previously had resisted viable culture conditions,» said Ozdener

To investigate whether miR - 181a plays a role in these effects, we transfected SH - SY5Y cells, which are a well - established model of human mDA neurons [18,38], with an miR - 181a inhibitor / antagomir.

Our study outlines the major sources of genetic and phenotypic variation in iPS cells and establishes their suitability as models of complex human traits and cancer.

The advent of human - induced pluripotent stem cell (hiPSC) technology has provided a unique opportunity to establish cellular models of disease from individual patients, and to study the effects of the underlying genetic aberrations upon multiple different cell types, many of which would not normally be accessible.

As an additional example, established anticonvulsant effects of ketogenic diets in humans and rats are countered by only mixed success in mice in various seizure models.54, 55, 56 Therefore, mice might be a challenging model for exploring the relationship between a ketogenic diet and pain and inflammation.

«Given the long and established history of curcumin as a spice and herbal medicine, its demonstrated chemopreventive and therapeutic potential, and its pharmacological safety in model system, curcumin, the bioactive extract of curcumin, promises a great future in human clinical studies designed to prevent and / or delay age - related diseases,» explained the authors of a review on these and other animal studies involving curcumin.

These and countless other experiments in mouse and human models have firmly established the role of the microbiome in energy homeostasis.

As the book's title suggests, the best model for parents and teachers — honed over millennia of human evolution and trial and error — is not the carpenter who works diligently from an established blueprint, but the patient gardener who provides a safe space to let nature take its course, and then gets out of the way.

The 2012 model focuses on establishing human capital management systems (HCMS) in all of the schools.

We have established laboratory techniques and animal models that have been used to study regenerative therapies for veterinary and human medicine.

Several organizations have asked Congress and the President to help establish a program for rescuing animals modeled on the American Red Cross human disaster relief plans, and a bill has been introduced in the US Senate to require states to include evacuation plans for pets in order to receive federal disaster planning funds.

«Establishing an animal model is paramount for testing new treatment and prevention modalities, especially for lesions that express none of the targeted receptors, such as triple - negative types, before human clinical trials,» Mohammed said.

These mutations establish CMR as a novel animal model for Best macular dystrophy (BMD) in humans, an autosomal dominant, childhood retinal disease also caused by mutations in the Bestrophin gene [76, 77].

If the United Nations remains the best role model for cooperative efforts to maintain peace internationally, protect human rights, and provide humanitarian aid, then what if we established a United Nations made up of ordinary people rather than diplomats?

If the United Nations remains the best role model for cooperative efforts to maintain peace internationally, protect human rights, and provide humanitarian aid, then what if we established a United Nations made up of

Machines are not really copying intelligent human behaviour, software is being created that can «learn» by comparing recently uploaded data with previous models and establishing commonalities.

These are organizations that have established creative, proactive, and valuable people management or human resource management practices, in various areas to the extent of being considered as a champion and a role model for others to follow.

Results - driven Director - Level human resources professional with 16 years experience in strategic planning to establish model performance expectations, manage change and transition, improve workforce performance, and amplify achievement of the organization's overall mission and profit goals.

MiTEAM: Michigan's Child Welfare Practice Model (WORD - 148 KB) Michigan Department of Human Services (2012) Establishes a unified approach to improve family engagement practices, provides consistency in practice, clarifies roles and expectations, informs policy and training, and encourages family - driven solutions.