If any analyses of the five shuffled data sets did not give similar
estimates of a major gene as the analyses from the original data, H0 was rejected, and the existence of a major gene was considered as likely.
Estimates of major gene variance were high in both HD and ED in all breeds studied.
In the German Shepherd, the Golden Retriever, and the Labrador Retriever,
estimates of the major gene variance for ED from the shuffled data sets were, at least in one data set, similar to the estimates obtained from the original data.
If the detection of a major gene were caused by for example environmental factors, shuffling the data would not affect
the estimate of the major gene variance.
Not exact matches
Estimates of the same magnitude for ED
major gene variance were obtained from both the original and shuffled data sets in the three breeds, excluding the Rottweiler.
The relatively high
estimates of the frequencies
of the unfavourable recessive alleles in each breed, especially for hip dysplasia, suggest that it would be possible to gain considerable genetic progress by selection against a
major gene.
The
estimates of the variance components suggest that the mode
of inheritance
of hip dysplasia is quantitative, with a
major gene affecting the trait jointly with numerous minor
genes.
The favourable allele A1 was dominant in every breed, based on the negative
estimates of the dominance effect d at the
major gene.
Estimated nonparametric marginal densities for polygenic (σ2u) and
major gene (σ2w) variance for elbow dysplasia (ED) in the Golden Retriever, as an example
of all breeds.
Estimated nonparametric marginal densities for polygenic (σ2u) and
major gene (σ2w) variance for hip dysplasia (HD) in the German Shepherd, as an example
of all breeds.
Relatively high
estimates of the frequencies
of unfavourable alleles in each breed suggest that considerable genetic progress would be possible by selection against
major genes.