Nevertheless, the balance of sex hormones appears important as inappropriate low testosterone, or high
estrogen concentrations in males, may also relate to fatty liver disease and metabolic abnormalities.
This suppression leads to
low estrogen concentrations and anovulation with a resulting period of lactational amenorrhea and, therefore, has been investigated as a potential factor related to EOC development (10).
Noting that
high estrogen concentrations are «a defining characteristic of dominant follicles,» Dr. Denis Magoffin (Ceders - Sinai Medical Center, Los Angeles, California, USA) and co-investigators examined whether abnormal expression of ERs could contribute to poor follicular development and ovulatory failure in women with PCOS.
Effects on progesterone and
estrogen concentrations in the plasma, placenta, and myometrium.
Rosenthal KL, Peterson ME: Evaluation of plasma androgen and
estrogen concentrations in ferrets with hyperadrenocorticism.