That means women eating cereal with soy milk and drinking a soy latte each day are effectively getting the
same estrogen effect as if they were taking a birth control pill.
Menopause is associated with decrease of total energy expenditure due to the loss of
estrogen effects on the hypothalamus via increased release of orexigenic hormones NPY, agouti - related peptides, and a decrease in lean body mass (67).
Therefore, the mechanism proposed behind decreased female central insulin sensitivity is a modulation caused by brain estrogen signaling, potentially mediated
by estrogen effects on ERα in various regions of the hypothalamus.
Interestingly,
estrogen effects within the brain with consequent alterations of leptin and insulin sensitivity could also be verified in male animals after estrogen administration (262).
However, diabetes impairs endothelial response in women more dramatically than in males modifying the beneficial
hemodynamic estrogen effects by complex interactions between insulin and estrogen signaling.
For severe cases, doctors sometimes prescribe Danazol, a steroid derivative that decreases levels of the reproductive hormones FSH and LH, or tamoxifen, a breast - cancer drug that helps relieve breast pain by blocking estrogen receptors, thus
preventing estrogens effect on breast tissue.
The reasons for this link is not entirely known, but one strong hypothesis is that adipose tissue may
increase estrogen effects.
Diindolylmethane might act like estrogen in the body, but there is evidence that under certain circumstances it might also
block estrogen effects.
But it activates them weakly so if you've too much estrogen, the flax competes for the estrogen by binding to receptors preventing those hyper - estrogenic effects and if you don't have enough estrogen, so in the case of post-menopause or ovarian failure, flax binds to estrogen receptors and causes
the estrogen effects that we really want, like libido and energy and the expression of female sex characteristics.