The use of
estrogen hormone therapy in sizable amounts in dogs is not without serious risk.
I am a 59 year old woman, who had a hysterectomy at age 49, followed by
estrogen hormone therapy, which resulted in breast cancer the following year.
Not exact matches
(Progesterone is added to
hormone therapy to protect the uterus lining from a risk of cancer seen with
estrogen alone.)
Recently, Manson and colleagues published a long - term study of the risk of death in women in the two WHI
hormone therapy trials — combined
therapy and
estrogen alone — from the time of trial enrollment in the mid-1990s until the end of 2014.
By replacing the natural
estrogen lost during menopause,
hormone replacement
therapy could be one way for women to regain the cardiovascular benefits of
estrogen, Arnson said.
Hormone replacement
therapy (HRT) is a system of medical treatment for perimenopausal and postmenopausal women, based on the assumption that it may prevent discomfort and health problems caused by diminished circulating
estrogen hormones.
In 2001 the trend reversed: Breast cancer rates initially dipped gradually, but dropped sharply in mid-2002, when many women in the U.S. stopped
hormone replacement
therapy after the Women's Health Initiative, a large clinical trial involving
estrogen - progestin
therapy, was stopped after it was determined that the risks — most notably the increased likelihood of developing breast cancer — outweighed the benefits.
The U.S. study testing the long - term benefits and risks of
hormone replacement
therapy (HRT) was halted after an interim analysis found that the drugs — a combination of
estrogen and progestin — increased the risk of breast cancer, stroke, and heart disease, and that those risks outweighed reduced risks of colorectal cancer and bone fractures (ScienceNOW, 9 July).
«Although oral
estrogens are effective for managing menopause symptoms, not enough is known about the cardiovascular safety of different oral
hormone therapy products relative to each other,» said first author Nicholas L. Smith, PhD.
Researchers at the Kaiser Permanente Center for Health Research in Portland, Ore., concluded there is definitely a link between breast cancer and the use of menopausal
hormone therapy, particularly
estrogen - progestin treatment combinations.
Since the report that it did cause breast cancer and many women have stopped taking
hormone replacement
therapy, we've seen a decrease in breast - cancer incidence, exactly what you'd predict for our understanding of how
estrogens work.
The drop in
hormone use dates back to July 2002, when the Women's Health Initiative, a 15 - year study tracking the health of more than 160,000 women, abruptly ended its long - term study of
estrogen - progestin
hormone replacement
therapy because women taking the drugs faced an elevated risk of invasive breast cancer and heart disease.
More discouraging news about
hormone replacement
therapy for menopausal women appeared in June: Women taking Prempro, the most widely prescribed pill containing both
estrogen and progestin, are more likely to develop Alzheimer's and to have early breast tumors that go undetected by mammograms.
By supplying the correct amounts of
estrogen and progesterone via
hormone therapy, it is relatively easy to make the uterus of a postmenopausal woman hospitable to a fetus.
Triple - negative cancers are so called because they do not express receptors for the
hormones estrogen and progesterone, nor for HER2 (human epidermal growth factor 2), and hence patients with these cancers are not candidates for treatment with modern hormonal
therapies or the highly effective HER2 - targeted drug Herceptin (trastuzumab).
«Some
hormone therapy - resistant cancers can be treated with
estrogen,» said Ellis.
Hot flashes are particularly severe and frequent in breast cancer survivors, but current FDA - approved remedies for these unpleasant episodes, such as
hormone replacement
therapies are off - limits to breast cancer survivors because they include
estrogen.
Hunt and colleagues exposed some newborn mice to BPA and some newborn mice to a synthetic
estrogen used in birth control pills and
hormone therapy.
Because most breast cancers are
hormone receptor - positive (i.e., they use
estrogen or progesterone to grow and spread), survivors often rely on
hormone therapy, such as AIs, to keep the disease from returning.
Gwendolyn Thomas, assistant professor of exercise science, is the co-author of a groundbreaking article in the Obesity Journal (The Obesity Society, 2017) about the effects of exercise and physical activity on postmenopausal breast cancer survivors taking AIs —
hormone -
therapy drugs that stop the production of
estrogen.
Potential cardioprotection was based on generally supportive data on lipid levels in intermediate outcome clinical trials, trials in nonhuman primates, and a large body of observational studies suggesting a 40 % to 50 % reduction in risk among users of either
estrogen alone or, less frequently, combined
estrogen and progestin.2 - 5 Hip fracture was designated as a secondary outcome, supported by observational data as well as clinical trials showing benefit for bone mineral density.6, 7 Invasive breast cancer was designated as a primary adverse outcome based on observational data.3, 8 Additional clinical outcomes chosen as secondary outcomes that may plausibly be affected by
hormone therapy include other cardiovascular diseases; endometrial, colorectal, and other cancers; and other fractures.3, 6,9
Postmenopausal
hormone therapy with conjugated equine
estrogens (CEEs) was not associated with overall sustained benefit or risk to cognitive function when given to women ages 50 to 55 years, according to a new study from Wake Forest Baptist medical Center.
But Suzanne Somerss
hormone therapy — she takes bioidentical
hormones, injects her vagina with a
hormone called estriol, and rubs
estrogen or progesterone cream on her arms every day — has put her in the limelight.
Sandi's doctor suggested
hormone replacement
therapy (HRT) or
estrogen replacement
therapy (ERT), which can improve mood changes and other symptoms related to low
estrogen levels during early menopause.
Many women are concerned about taking
estrogen orally —
hormone replacement
therapy or HRT — after a 2002 study suggested a strong link to breast cancer, but doctors have widely divergent opinions about that.
Cancers that are positive for
estrogen receptors, progesterone receptors, and HER2 can be treated with
hormone therapies and drugs that target HER2.
«In the Womens Health Initiative (WHI) trial, when women got seven years of
estrogen alone, there was no increased risk of breast cancer, but after four to five years on combined
hormone therapy, the risk emerges,» she says.
Low doses of prescription medications, including antidepressants, can help relieve hot flashes in overweight women who need immediate relief, Dr. Nachtigall says, as can
hormone therapy, which replaces
estrogen and other
hormones that decline during menopause.
While long - term use of traditional
hormone replacement
therapies, which include
estrogen and progestin, are no longer recommended due to the heart and health risks, there are other options.
If your body has stopped producing a normal amount of testosterone,
estrogen, or progesterone,
hormone replacement
therapy may be the only recourse.
Whether that treatment protocol turns out to be
estrogen replacement
therapy or testosterone replacement
therapy, for women, the right
hormone replacement
therapy can be a game changer — click the button to find out more.
It is not synthetic (the negative press of 20 years ago regarding HRT
therapy had to do with synthetic
hormones — primarily
estrogen — and not growth
hormone), and should never be confused with synthetic steroids.
Research has shown that bioidentical
estrogen is important for both safety and improved effectiveness, which is why we only use bioidentical
hormones in
estrogen replacement
therapy.
The treatment for weight gain associated with low
estrogen or low testosterone is
hormone replacement
therapy.
Estrogen replacement
therapy has long been understood as a remedy for women who are suffering from a variety of side effects following menopause, but what many women don't know is that testosterone replacement
therapy may also need to be added to the mix to properly balance
hormone levels.
To understand how
estrogen therapy works, we look at what happens when
hormone production slows down.
When we recommend
hormone replacement
therapy, we're looking to improve your overall hormonal balance — treatment for perimenopause isn't just about
estrogen levels.
Testosterone and
estrogen receive the most attention in the world of
hormone replacement
therapy, but the action of progesterone may be just as important.
In a group of women 65 to 80 years of age who had never used
hormone replacement
therapy of any kind, blood levels of estradiol (one of the human
estrogens) were measured.
When I counsel a woman about taking
hormone therapy, I recommend bioidentical
estrogen and progesterone, including transdermal estradiol and oral progesterone, but with an important caveat: I assume that the risks of bioidentical
hormone therapy are the same as synthetic until proven otherwise.
Description: Many oral contraceptives (birth control) and post-menopausal
hormone replacement
therapy products contain
estrogen.
From L.A. Times Staff and Wire Reports June 6, 1995 Contrary to much current medical thinking, long - term use of
hormone replacement
therapy may significantly increase the risk of breast cancer in postmenopausal women, even when progestins are added to
estrogen, according to a new study.
Estradiol is a form of
estrogen you need to monitor if you're receiving
hormone replacement
therapy.
When I counsel a woman about taking
hormone therapy, I recommend bioidentical
estrogen and progesterone, including transdermal estradiol and oral progesterone, but with an important caveat:
While taking synthetic forms of progesterone and
estrogen was a popular method of addressing menopause symptoms for a while, many women - and doctors - now feel
hormone replacement
therapy is simply not worth the risk.
For the same reasons of safety and efficacy, we only use bioidentical
hormones for
estrogen replacement
therapy.
The good news is, there are
hormone replacement
therapies, like
estrogen replacement, that we often recommend to return your
hormones to more regular levels and help keep you looking and feeling like yourself.
Women can have too much
estrogen from birth control pills,
hormone replacement
therapy (such as Premarin or
estrogen creams), perimenopause, menopause, and even pregnancy.
Even medications can interfere with other
hormones: birth control pills,
estrogen replacement
therapies, and beta - blockers can disrupt the thyroid function and contribute to less than optimal
hormone balance.
Although bio-identical
hormone therapy seems to work for most post-menopausal women for arthritis relief, there are a few women that still have arthritis and arthralgias in spite of the
estrogen cream.