Increased catechol
estrogen metabolism as a risk factor for nonfamilial breast cancer.
Genetic modeling of
estrogen metabolism as a risk factor of hormone - dependent disorders.
Not exact matches
Studies have also suggested that it disrupts the production of hormones such
as testosterone, prolactin (which stimulates the production of breast milk), progesterone,
estrogen, and the thyroid hormones that regulate
metabolism.
There is some evidence of poor iron
metabolism and high
estrogen levels
as causative factors for RLS, but with menopause RLS doesn't tend to improve so the details of the hormonal and nutrient deficiency etiologies are RLS are not yet clear.
However, 16α - OH estrone is also involved in bone building, so very low levels indicate increased risk for osteopenia / osteoporosis in men
as well
as women.29303132333435 Confirming this, a positive family history of osteoporosis has been found to be associated with preferential
metabolism of
estrogen through the inactive 2 - OH pathway.36
Other B vitamins to supplement with are B6 and B12
as they help folic acid
metabolism estrogen into their anti-cancer form.
On top of all the nasty symptoms and a blocked
metabolism, if not properly balanced out,
estrogen dominance may lead to endometriosis, fibroids, hormone - related cancers (such
as breast cancer), and metabolic syndrome.
Nutritional supplements such
as Indole -3-carbinol and Di - Indole - Methane (
Estrogen Metabolism Diet Cancer) are known to adjust the 2/16 ratio into a higher, more favorable balance.
Regulating thyroid function and
metabolism will effectively lower nitric oxide levels,
as can addressing the underlying
estrogen dominance, which we often do with our Molecular Progesterone Oil and our Vitamin E Complex.
Many important hormones are made of cholesterol, including hormones that regulate mineral
metabolism and blood sugar, hormones that help us deal with stress, and all the sex hormones, such
as testosterone,
estrogen and progesterone.
In addition, a slow
metabolism of
estrogen, which leaves too much unmetabolized active
estrogen known
as estradiol in the body, can be a problem for both women and men.
The results indicated that supplemental DIM acted
as a dietary antiestrogenic supplement through enhanced
estrogen metabolism, possibly decreasing the likelihood of women to develop TPD.
Beware
as well of DIM (Diindolylmethane) and other supplements said to bind excess
estrogen or regulate
estrogen metabolism.