Estrogen metabolites are the byproducts or substances that are created when estrogen, a type of hormone in the body, undergoes chemical changes or reactions. These metabolites can provide valuable information about hormonal balance and health.
Full definition
Estrone's oncogenic metabolites, 4 - hydroxyestrone (4 - OH estrone, considered the most
carcinogenic estrogen metabolite) and 16α - OH estrone (which is needed in small amounts because of its bone - building actions), are produced by Phase I metabolism.
But it's a much bigger player in estrogen; your liver breaks down estrogen and
unhealthy estrogen metabolites such as 8 - hydroxy - estrogen and 16 - hydroxyestrogen.
I speculated that its benefits are likely due not to lowering overall estrogen, but by helping the liver to produce
beneficial estrogen metabolites instead of unhealthy ones.
Instead, they charted levels of 32
other estrogen metabolites — some of which are precursors of the dangerous quinones and some of which signal that the quinone - clean - up crew has been kept busy.
Yes, high levels of the unhealthy
estrogen metabolites do cause cancer cell proliferation, but that doesn't mean that consumption of Estroblock will be enough to make a large scale difference.
Secondly, the aforementioned improved metabolization of hormones could help to reduce unhealthy
estrogen metabolites like 4 - hydroxy and 16 - hydroxy estrogen.
DIM may even clear acne;
toxic estrogen metabolites may create pimples by causing inflammation and depleting your precious antioxidant supplies.
Furthermore, indole -3-carbinol reduces 4 - OH and 16 -
OH estrogen metabolites, both of which are associated with increased breast cancer risk and PMS symptoms.
These
beneficial estrogen metabolites are released into the bloodstream and account for many benefits previously attributed to estrogen, such as, prevention of heart disease, the building of strong, healthy bones, and soft, supple skin.
When your thyroid isn't working well it can unbalance
your estrogen metabolite ratio.
Lab tests: Dried urine testing (see cortisol) with
all estrogen metabolites, or salivary female hormone panel.
This causes harmful
estrogen metabolites to re-circulate throughout the body.
We have to look at what is feeding the growth and development of the fibroids — is it elevated estrogen, or
estrogen metabolites.
DIM in high doses, supports the metabolism of estrogen resulting in an increased level of healthy
estrogen metabolites while reducing the level of carcinogenic estrogen metabolites.
Estrogen metabolites that have been shown to impact estrogen - related cancers (more detail provided in Part II of this article) offer a prime example:
Estrogen metabolites are the byproduct of estrogen metabolism and have important biological functions to perform, though not all estrogen metabolites are benign.
Phase 1 detoxification is when DIM helps to break down
the estrogen metabolites, but after that phase 2 kicks in.
Urine - based fertility monitors base their prediction on the presence of a specific level of
an estrogen metabolite in urine.
High estrogen (or
estrogen metabolites) can be the cause of tender breasts, mood swings, hair loss, weight gain, fibroids, endometriosis, breast and ovarian cysts and even breast and ovarian cancer.
DIM (Diindolylmethane) has been shown to help regulate and promote a more efficient metabolism of estrogen, and an optimal ratio of
estrogen metabolites.
When DIM increases the «good»
estrogen metabolites, there is a simultaneous reduction in the levels of undesirable or «bad» estrogen metabolites.
These «bad»
estrogen metabolites are responsible for many of estrogen's undesirable actions in women and men, including further unwanted weight gain, breast cancer, and uterine cancer.
Supplementing the diet with DIM and eating cruciferous vegetables increases the specific aerobic metabolism for estrogen, multiplying the chance for estrogen to be broken down into its beneficial, or «good»
estrogen metabolites.
DIM supplements actively promote a desirable estrogen metabolism that produces more of the «good»
estrogen metabolites, known as 2 - hydroxy estrogens.
Greater production of these «bad»
estrogen metabolites is promoted by obesity and exposure to a number of manmade environmental chemicals.