Sentences with phrase «estrogen signaling»

These cells had previously been shown to reactivate estrogen signaling in order to acquire drug resistance.

Therefore, the mechanism proposed behind decreased female central insulin sensitivity is a modulation caused by brain estrogen signaling, potentially mediated by estrogen effects on ERα in various regions of the hypothalamus.

It is possible that Notch regulation by estrogen is context dependent, but our data clearly show that hypoxia activates estrogen signaling, resulting in increased Notch1 cleavage and activation of downstream targets.

The authors make an interesting point, «The increased risk of death due to cancer observed in sterilized dogs could be due to the fact that in both sexes, dogs sterilized before the onset of puberty grow taller than their intact counterparts as a result of reduced estrogen signaling.

However, diabetes impairs endothelial response in women more dramatically than in males modifying the beneficial hemodynamic estrogen effects by complex interactions between insulin and estrogen signaling.

When a second estrogen receptor, named ERbeta, was discovered 20 years ago this changed the paradigm of our understanding of estrogen signaling, and the new receptor was thought to be a very promising candidate for complementary breast cancer treatment.

This potential clinical implication of our study takes on additional significance because there has been little further success in developing breast cancer chemoprevention since the introduction of inhibitors of estrogen signaling (Hutchinson, 2011; Lyons et al., 2011).