Estrogen metabolism and risk of breast cancer: a prospective study of the 2:16 alpha - hydroxy -
estrone ratio in premenopausal and postmenopausal women.
Not exact matches
(1) The 2 / 16α
ratio: a decrease in this
ratio of the
estrone metabolites, 2 - hydroxyestrone and 16α - hydroxyestrone, is associated with an increased risk of breast and cervical cancer.
Here is a fascinating data point: flaxseed does not only suppress estradiol production but it also nudges estradiol metabolism into a positive direction by generating a higher
ratio of the protective metabolite 2 - hydroxy -
estrone versus the more harmful 16 - hydroxy -
estrone.
Ratios of estrogen metabolites (16 - OH / 2 -0 H
estrone) can also be checked to identify an increased risk of breast and other cancers.