Of the 126 affected dogs that have died, 76 deaths (60.3 %) were directly attributed to the seizure disorder, with the cause of death reported as death during seizure (16.1 % of all seizure related deaths) or euthanasia because of uncontrolled seizures (65.8 %), hepatotoxicity from phenobarbital treatment (6.6 %), aspiration during seizures leading to fatal pneumonia (6.6 %), or euthanasia because of non-recovery after a seizure (3.9 %
Of the 126
affected dogs that have died, 76 deaths (60.3 %) were directly attributed to the seizure disorder, with the cause
of death reported as death during seizure (16.1 % of all seizure related deaths) or euthanasia because of uncontrolled seizures (65.8 %), hepatotoxicity from phenobarbital treatment (6.6 %), aspiration during seizures leading to fatal pneumonia (6.6 %), or euthanasia because of non-recovery after a seizure (3.9 %
of death reported as death during seizure (16.1 %
of all seizure related deaths) or euthanasia because of uncontrolled seizures (65.8 %), hepatotoxicity from phenobarbital treatment (6.6 %), aspiration during seizures leading to fatal pneumonia (6.6 %), or euthanasia because of non-recovery after a seizure (3.9 %
of all seizure related deaths) or
euthanasia because
of uncontrolled seizures (65.8 %), hepatotoxicity from phenobarbital treatment (6.6 %), aspiration during seizures leading to fatal pneumonia (6.6 %), or euthanasia because of non-recovery after a seizure (3.9 %
of uncontrolled seizures (65.8 %), hepatotoxicity from phenobarbital treatment (6.6 %), aspiration during seizures leading to fatal pneumonia (6.6 %), or
euthanasia because
of non-recovery after a seizure (3.9 %
of non-recovery after a seizure (3.9 %).
Clinically
affected dogs are often young (3 - 18 months
of age) and present with poor weight gain, progressive peripheral neuropathy including ataxia, leg crossing, tremors and paresis which worsens with exercise.Behavioral changes, blindness, dementia, anorexia, cachexia, urinary incontinence and muscle weakness
affecting all four limbs are usually present in terminal stages
of the disease with death occurring 2 - 6 months after onset
of clinical signs, necessitating
euthanasia.