Sentences with phrase «evade immune»

T. pallidum is also very wily, with the ability to evade our immune response.

By hiding inside the host cells, preventing immune response, and destroying antibodies, the bacteria are fully equipped to evade the immune system.

In tumorous cells an error has occurred in this script, allowing the cells to grow out of control and evade the immune system policemen in charge of preventing it.

That is, if you can catch a disease more than once, it has developed a genome (genes) that help it evade the immune system.

We learn how diseases try to evade the immune system, how they exploit vulnerabilities and even subvert it to their own advantage, and we discover how scientists are designing new drugs to harness the power of the system to advance medicine in the 21st century.

«Cancer is notorious for its ability to evade immune detection,» says pioneering mycologist Paul Stamets, who was also Director of Research for the study.

With a number of infections, the body's immune system is able to kill the majority of pathogens, but a small amount of pathogens are able to evade the immune system.

This diversity is thought to contribute to the antigenic variability of the spirochete to evade being picked up on Lyme testing, evade the immune system and antibiotic therapy, leading to chronic infection.

Building on each other's work, the five award recipients demonstrated how this normal self - defense mechanism can be hijacked by tumors as a way to evade immune surveillance and dodge an attack.

Revealed that the loss of the human leukocyte antigen (HLA) locus in lung cancers is a way these tumors evade the immune system and allow mutation expansion and branched evolution within tumor cells

Collectively, their work has elucidated foundational mechanisms in cancer's ability to evade immune recognition and, in doing so, has profoundly altered the understanding of disease development and treatment.

We are also not yet able to accurately detect changes in key regions of the Plasmodium genome including, for example, the hypervariable var genes, which contribute to the parasites» ability to evade our immune system.

By increasing the production of CD47, cancer cells have the ability to evade the immune system.

«This pathway enables multiple tumor types to evade immune surveillance.

More importantly, Gack found that avian, swine, and human flu viruses block TRIM25 to evade immune defense by RIG - I, unraveling a molecular target for the design of antiviral drugs and vaccines.

Tumors use adenosine as an important process to evade immune attack and promote their survival.

Interestingly tumor cells, whilst not allogeneic, are in many cases both «altered - self» and immunogenic but often actively modulate immune responsiveness to evade immune surveillance 76.

Cancer cells are able to use the normally healthy process of inflammation to promote their own growth and evade immune detection.

Douglas Hanahan and Robert Weinberg publish an update of their seminal review, Hallmarks of Cancer, adding to the list of cancer characteristics the ability of tumors to evade the immune system and emphasizing immune system - induced inflammation as an enabling characteristic in cancer development.

A solution, Cheng and his colleagues thought, could be to grow blood cells in the lab that were matched to each patient's own genetic material and thus could evade the immune system.

«Scientists provide new insights on how cancers evade the immune system.»

«Given the lack of universal HPV immunization and the potential for the virus to evade the immune system even in individuals with detectable HPV in their blood, our findings could have far - reaching implications for identifying people at risk of developing HPV - related head and neck cancers and ultimately preventing them,» Miller said.

Then a mutant offspring, one that is different enough to partly evade the immune reaction directed against its parent, takes over and dominates the next year's epidemic.

Upon infection, viral enzymes alter ubiquitin pathways in a way that allows the virus to evade the immune defense while multiplying and destroying the host tissue as it spreads in the body.

T. cruzi is already known to disguise its cell surface with human proteins and sugars: apoptosis would be yet another weapon in the arsenal that helps it evade the immune system.

The analysis also showed that the bacterium seems very adept at shuffling its genes — an ability that may help it evade the immune system.

The research may also provide information as to how other bacteria evade the immune system and be unaffected by antibiotics.

Its diversity is also its greatest asset: the ability to change two proteins on its surface — H and N in shorthand — lets it evade the immune system and complicates the work of drug - and vaccinemakers.

For a malignant tumor to form, cancer cells must evade the immune system's attack.

In cancer, the protein helps malignant tumors evade the immune system as they metastasize and alter their microenvironment in a stealth type of expansion.

Dr. Ernst says that if such an antigen transfer system works to boost the immune response in TB, then a similar bypass mechanism could also be at work in other infectious diseases in which the invading microorganism has developed means to evade the immune system.

The answer to increasing the effectiveness of immune therapies, or perhaps at least to choosing which patients are most likely to benefit from immune therapies, may lie in understanding the ways viruses (and cancers themselves) have evolved to evade the immune system.

PD - 1 (programmed cell death protein 1) is a receptor on the surface of T cells (the white blood cells that are part of the immune system), while PD - L1 (programmed death - ligand 1) is a molecule that binds to PD - 1 and is often over-expressed on the surface of cancer cells, enabling them to evade the immune system and allow cancer to grow and spread.

Researchers have long speculated that viruses and other infectious agents could trigger MS.. Many pathogens are thought to evade the immune system using a cloaking strategy called molecular mimicry.

Current vaccines target the head, which is the part of the virus that's always changing in an effort to evade our immune defenses.

But cancer cells put out signals that help them evade immune response, say the authors.

Now, thanks to the new mouse model, it will be possible to study how renal tumors are able to develop in an environment with a normal immune system, and how cancer cells manage to evade the immune system's attacks.

When they sequenced the complete genomes of the Y. pestis DNA in those seven individuals, the team found that the bacterial genomes from the earliest samples lacked two genes that helped Y. pestis evade the immune systems of humans and fleas during the Black Death.

These genetic miscues can cause cells to grow out of control, evade the immune system, or fail to execute essential functions needed to maintain health.

After treatment with AZA, the epigenetic changes were reversed, rendering the cancer cells unable to evade the immune system any longer.

The team is now working on showing exactly what changes the bisphosphonates cause in the macrophages, something which could help us understand exactly how cancer is able to evade the immune system.

The new «trivalent» vaccine induces antibodies against three different parts of the virus, including two components that normally help HSV2 evade immune attack.

From year to year, those proteins usually undergo just enough change to evade the immune system.

«This confirmed our theory that both pathogenic and commensal bacteria can only survive in a host organism if they can escape or evade the immune system,» says Götz.

Tumors typically have a repertoire of molecular defenses they can use to suppress or evade immune attacks, which is why cancer vaccines and immunotherapies have had mixed results in clinical trials to date.

As a result, the virus has to mutate so that the protein will be different enough to evade the immune system.

In other words, bacterial prions, could boost bacteria's ability to cause disease, evade immune system surveillance and elude drugs.

To take root and grow, a tumor must evolve mechanisms over months or years to evade immune attack.

Flu viruses can evade immune - system scouts by constantly shifting surface antigens.

The study results builds on prior investigations by the research team which demonstrated that activation of the PI3K pathway by PTEN tumor loss created a «microenvironment» allowing tumors to evade immune suppression.