Sentences with phrase «even at the highest dose»

If the first medicine doesn't seem to work, even at the highest dose, then a doctor may try a different medicine.

The drug, daratumumab, proved generally safe in patients, even at the highest doses tested in the study.

Citalopram, the most commonly prescribed drug among patients in the study, was not associated with an increased risk of arrhythmia, even at higher doses.

In some cases, patients» tumors develop resistance to Gleevec — either the Abl protein mutates so that the drug can no longer bind to it, or the protein accumulates in such quantities that the drug can't keep up, even at the highest dose.

Sucralose has shown no carcinogenic effects in animals, even at high doses.

The benzoxazine compounds were synthesized by altering the ring core structure, preventing toxicity even at high doses.

News that the trial is fully recruited and the final patients are going through the procedures is a strong suggestion that even at the highest doses, the drug's safety looks good.

«What we find is that dabrafenib, even at high doses, does not fully turn off the MAPK pathway, thereby enabling eventual escape from drug,» Spencer says.

Melatonin is not associated with liver toxicity even at high doses (up to 20 mg / day) for prolonged periods of administration (up to 12 weeks) in both adults and children.

Spirulina has a record of safety, even at high doses, 17 with few reported side effects.

And numerous studies conducted to test the herbs» toxicity levels have shown that Tongkat Ali is safe to be consumed even at higher doses.

They have virtually no toxic side effects, even at high doses, and can be used in patients ranging from pocket pets to dogs, cats, birds and even horses.

Not exact matches

Adults with coronary heart disease should make sure they get at least 1000 mg each day and even higher doses if they have high triglyceride levels.

Even a high dose of synthetic oxytocin (Pitocin) is unlikely to trigger labor until a woman is at term.6

It's even more repulsive in light of a recent study by Dr. Andrew Chang of Albany Medical Center, published in the Journal of the American Medical Association, showing opioids were no more effective at reducing pain for patients with broken limbs than a high - dose combination of the over-the-counter, non-addictive painkillers ibuprofen and acetaminophen.

Even more troubling, her study found a link between high blood levels of lycopene's chemical cousin, beta - carotene, and an increased risk of aggressive prostate cancer — not enough to justify avoiding carrots and other food sources of beta - carotene but an ominous sign that not all food - derived compounds are necessarily benign when taken at higher doses.

However, when participants exercised at an intensity that was greater than 92 % of their HRmax during the high - intensity periods, the effect was even greater than at the lower intensity levels, indicating that there is a dose - response relationship even in the 85 - 95 % high - intensity zone.

And to Gould's surprise, the metabolite did not cause side effects in the mice even at doses nearly 40 times higher than the antidepressant dose of ketamine.

* The ACC / AHA cholesterol treatment guideline recommends prescribing the strongest statins at high doses to most men older than 65, even those with no history of heart disease, or any major risk factor for heart attacks, and with normal cholesterol levels.

Finally, these benefits emerged without any adverse side effects, even at SW033291 doses much higher than would be required for 15 - PGDH inhibition.

The researchers also showed that the nitroxide BASP nanoparticles are not harmful to mice even at very high doses.

TIC10 seems to be nontoxic to normal cells or mice even at doses 10 times higher that an observed therapeutic dose, however more research needs to be completed to satisfy FDA requirements prior to initiation of clinical testing.

You know what else can irritate the eyes and skin and even cause digestive problems at high doses?

Gels don't work well for women because you often won't absorb them properly (and even if you do, the gels weren't made at the correct dose for you — they were made with much higher doses for men).

At even moderate doses, synthetic Vitamin A can be problematic, though the same problems are not noticed in most high doses of natural form.

Their digestion is not working at all even with the high dose of their enzymes.

As a matter of fact, any weight loss supplement that contains ingredients such as ephedra, high doses of caffeine, country mallow, or even orlistat (an ingredient in the weight loss supplement Alli) may put you at cardiovascular risk, damage your liver, stress your adrenals and cause intestinal irritation, gut damage and gastrointestinal upset.

This would suggest that those with darker skin tones should supplement at slightly higher doses because their bodies are even less likely to be able to produce adequate Vitamin D from the sun alone.

Curcumin is considered one of the safest medicinal spices in the world, even at high or mega doses.

Countless studies have been done and the consensus is that supplementation with creatine monohydrate is completely non-toxic and has no observable adverse effects, even when consumed at high doses (10 times higher than what I consume myself) and for long periods of time.

Natural phytochemicals at the low levels present in fruit and vegetables offer health benefits, but these compounds may not be effective or safe when consumed at higher doses, even in a pure dietary supplement form.

But at reasonable doses, or even considerably higher than the one or two servings a day Asian men eat, soy phytoestrogens do not exert feminizing effects on men.»

When a higher dose (400 mg) of green coffee bean extract was supplemented, there was an even greater average reduction in blood sugar — up to nearly 28 % at one hour.

This would explain the studies where people have shown a severe reaction to wheat — and no reaction at all to gluten itself, even in high doses.

But even the high dose at 25 mg / kg was only half the acceptable daily intake set by the FDA, so the FDA says one can safely consume 50 mg a day, but after just eight days on half that, participants had more irritable mood, exhibited more depression, and performed worse on certain brain function tests.

At low - moderate doses, something in a food can be quite healthy, even beneficial, but at very high doses we either plateau our efficacy or start to get into troublesome toxicitAt low - moderate doses, something in a food can be quite healthy, even beneficial, but at very high doses we either plateau our efficacy or start to get into troublesome toxicitat very high doses we either plateau our efficacy or start to get into troublesome toxicity.

My new GP has done all sorts of tests and 90 % of my readings show withing the norm, the only thing he found is I have too high reverse T3, for which he prescribed slow release T3, even upped the dose to 20 mg a day with 100 mg of L thyroxin, and still, the T3 buggers are still at the end of the bracket over 500 I mean.

IME, neither cause the runs even when slathered on at high doses daily, as long as not taken internally.

The toxic dose is dependant on weight, so little dogs are at higher risk, but with the higher levels of cocoa in chocolate products now even bigger dogs are at risk.

Levels of theobromine vary with types of chocolate (dark chocolates are higher in theobromine, white chocolates, lower), but any type of chocolate, even at small doses, may be hazardous.

Other picnic dangers include desserts made with xylitol, a natural sugar - free sweetener that with ingestion can result in an acute drop in blood sugar and even liver failure at high doses.

Recent research suggests that B12 pills at very high doses without intrinsic factor may work, however we have also observed failures with oral B12 if the intrinsic factor, even when not species specific, is not included.

Xylitol results in an acute drop in blood sugar and even liver failure at high doses, while grapes and raisins can result in severe, fatal acute kidney failure.

Even substances which are necessary for life itself become deadly at high doses.