For the first time, using sophisticated tools to measure skin color,
blood flow, and temperature, researchers found that patients on the drug who had a very rapid onset of flushing — redness, pain, swelling, and heat to the face — rated the experience far more harshly than patients whose skin
changed gradually,
even to the point of extreme redness or
change in temperature over time.
Unlike the findings reported by others, we did not observe
changes in umbilical and cerebral
blood flow,
even in the most serious cases.2 However, other questions concerning virus pathogenesis and consequences to fetal development remain unanswered.