Sentences with phrase «even in normal mice»

Dr. Verdin further found that prolonged intake of a high - fat diet, even in normal mice, can itself reduce the activity of the enzyme produced by SIRT3 — an enzyme his laboratory originally discovered.

Not exact matches

Even in the first week after an election, the Whitehall agents of the 800 lb gorilla of executive power are hard at work on the tiny but irritating squeak of the parliamentary mouse rather than fixing the broken democracy in partnership with parliament, «back to normal working» is not the slogan that will restore the reputation and capability of our democracy.

In contrast, control mice expressing the normal human prion sequence resisted infection when exposed to same materials — just as humans seem to, even those who consume venison meat.

Heijtz could even shift her germ - free mice towards «normal» behaviour and genetic activity by giving them a microbiome transplant, but this only worked early in their lives.

Normal mice, in contrast, exhibited no symptoms, even when given 10-fold higher doses of the substances.

Aside from a food intake in laboratory mice that's about 40 percent fewer calories than normal, however, it's been found that another way to activate this pathway is with rapamycin, which appears to have a significant impact even when used late in life.

Even though the mice appeared normal in many ways, they were unable to tune down their responses to external signals such as noises.

Post mortems showed that brain connections lost in the untreated mice remained healthy, and completely normal protein production had resumed in the treated animals, even though the prions continued to accumulate.

Mice whose fathers or even grandfathers have learned to associate the smell of cherry blossom with an electric shock become more jumpy in the presence of the same odour, and respond to lower concentrations of it than normal mMice whose fathers or even grandfathers have learned to associate the smell of cherry blossom with an electric shock become more jumpy in the presence of the same odour, and respond to lower concentrations of it than normal micemice.

The muscle fibers were larger and more numerous than in normal mice, and even after a year the mutant mice show no other abnormalities.

Abraham Kierszenbaum of the City University of New York Medical School has conducted experiments in mice showing that even normal - looking sperm from a mutant mouse «is likely to create infertile offspring.»

«With normal, wild type bacteria, the mice would die even if you treated them with the antibiotics,» Nguyen said in the podcast.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

Constructs lacking the RP sequence were barred from the mitochondria, and even constructs with appended RP were reduced to ~ 13 - 17 % of normal import into mitochondria from mice with a liver - specific, two - thirds reduction in levels of the murine PNPase homolog.

According to Diaz - Meco, when the researchers used an investigational drug that targets MDMs, they were able to prevent cancer progression in mice, and even restore normal pancreatic cell identity.

It was even lower in the early lesions of I10 mice than in those of age - matched virgin mice, suggesting that the molecular network activated in normal epithelia at involution to arrest the cell cycle (Figure 1 — figure supplement 3B) also operates in these premalignant cells.

However, when methionine - rich diets are used to induce hyperhomocysteinemia... Mice fed methionine - rich diets had significant atheromatous pathology in the aortic arch even with normal plasma homocysteine levels, whereas mice fed B vitamin - deficient diets developed severe hyperhomocysteinemia without any increase in vascular patholMice fed methionine - rich diets had significant atheromatous pathology in the aortic arch even with normal plasma homocysteine levels, whereas mice fed B vitamin - deficient diets developed severe hyperhomocysteinemia without any increase in vascular patholmice fed B vitamin - deficient diets developed severe hyperhomocysteinemia without any increase in vascular pathology.

Moreover, it should be noted that ketogenic diets are only relatively high in protein18, 106 and that some recent studies have demonstrated that VLCKD can even cause a regression of diabetic nephropathy in mice.109 With regard to possible acidosis during VLCKD, as the concentration of KBs never rises above 8 mmol / l10 this risk is virtually inexistent in subjects with normal insulin function.