Not exact matches
It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer,
even such a study would likely show less effect than could be anticipated in a
large mammal model, since
even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary
tumor volume is generally sufficient to be fatal to mice.
Researchers further state that, «The great majority of the
tumors remain small and circumscribed and
even from those few
tumors that grow
larger and become invasive OPCs only a minimal proportion will ever become a clinical carcinoma» (6, p. 531).
Answer: Many possibilities, including benign fatty
tumors, which are common in middle age and older dogs, which can
even get quite
large.
It can sometimes be treated successfully with surgery - but the surgery must be very aggressive, removing a
large amount of tissue surrounding the
tumor - possibly
even bone.
The
tumor can reach such a
large size that it will interfere with the rat's ability to move, groom itself, and
even eat.