A systematic review and meta - analysis of the psychosis continuum:
evidence for a psychosis proneness - persistence - impairment model of psychotic disorder
Not exact matches
For men and women combined, we found
evidence that the rate of non-affective
psychosis in refugees compared with migrants varied by region of origin (table 3 ⇓; likelihood ratio test P = 0.05).
The delicate balance between the human microbiome and the development of psychopathologies is particularly interesting given the ease with which the microbiome can be altered by external factors, such as diet, 23 exposure to antimicrobials24, 25 or disrupted sleep patterns.26
For example, a link between antibiotic exposure and altered brain function is well evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression, psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behavio
For example, a link between antibiotic exposure and altered brain function is well
evidenced by the psychiatric side - effects of antibiotics, which range from anxiety and panic to major depression,
psychosis and delirium.1 A recent large population study reported that treatment with a single antibiotic course was associated with an increased risk
for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behavio
for depression and anxiety, rising with multiple exposures.27 Bercik et al. 28 showed that oral administration of non-absorbable antimicrobials transiently altered the composition of the gut microbiota in adult mice and increased exploratory behaviour and hippocampal expression of brain - derived neurotrophic factor (BDNF), while intraperitoneal administration had no effect on behaviour.
Nevertheless, the
evidence in favor of an anti-DA mechanism
for the neuroleptics is very strong and does support the contention that increased DA is the mechanism of amphetamine
psychosis.
However, other types of
evidence suggest a dopaminergic basis
for amphetamine - induced
psychosis.
Despite growing
evidence of the effectiveness of cognitive — behavioural therapy (CBT)
for psychosis, typically only about 50 % of patients show a positive response to treatment.
Patients had to fulfil the following criteria: a diagnosis of schizophrenia, schizoaffective
psychosis, or delusional disorder according to criteria from the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, revised11; no
evidence of organic brain disease; substance abuse not identified as the primary problem; age between 18 and 65 years; presence of persistent hallucinations or delusions, or both,
for a minimum of 6 months and at least 1 month of stabilisation if they had experienced an exacerbation during this period; stable medication; no psychological or family intervention; their responsible medical officer had given permission
for them to enter the study; no serious threat of violence towards the assessors; and they had given informed consent to participate.
Systematic reviews of categorical versus continuum models in
psychosis:
evidence for discontinuous subpopulations underlying a psychometric continuum.
The methodological rigour of this study augments emerging
evidence that psychological interventions are effective in addition to medications
for patients with ongoing symptoms of
psychosis.
A pilot study of cognitive training in clinical high risk
for psychosis: initial
evidence of cognitive benefit