Sentences with phrase «evidenced in human diseases»

As evidenced in human diseases, defects in DNA repair induce senescence and degeneration of nervous and endocrine / exocrine tissues.

Not exact matches

Some of the marketing material highlighted in Lion's cross claim includes: «A2 will improve human health through the consumption of a2 dairy milk products», «studies suggest that milk containing only the A2 type of protein may benefit you and your family if you're concerned with certain allergies, immune function or digestive wellbeing» and «there is significant evidence to suggest that beta casein A1 may be a primary risk factor for heart disease in adult men and also be involved in the progression of insulin dependent diabetes in children... Beta casein A1... is the most powerful risk factor ever discovered.»

Research in the United States, Canada, Europe, and other developed countries, among predominantly middle - class populations, provides strong evidence that human milk feeding decreases the incidence and / or severity of diarrhea,1 - 5 lower respiratory infection,6 - 9 otitis media,3,10 - 14bacteremia, 15,16 bacterial meningitis, 15,17 botulism, 18 urinary tract infection, 19 and necrotizing enterocolitis.20, 21 There are a number of studies that show a possible protective effect of human milk feeding against sudden infant death syndrome,22 - 24insulin - dependent diabetes mellitus,25 - 27 Crohn's disease, 28,29 ulcerative colitis, 29 lymphoma, 30,31 allergic diseases,32 - 34 and other chronic digestive diseases.35 - 37 Breastfeeding has also been related to possible enhancement of cognitive development.38, 39

In evaluating the benefits of breast milk, the American Academy of Pediatrics conducted a review of the literature for evidence of disease reduction with the use of human milk.

Preliminary results of the study were presented at a World Health Organization (WHO) evidence review group meeting, while UNITAID has issued a call for further research into the use of endectocide class drugs, of which ivermectin is currently the only one registered for human use, as new vector control tools in the fight against malaria and other mosquito borne disease.

Cartan - Hansen described the importance of the research in determining whether the outbreak of white nose syndrome had reached southwestern Idaho (there was no evidence of it in the power plant building), and she noted that humans can spread the disease by transporting the fungus on their shoes and clothing from caves harboring infected bats.

«Despite the overwhelming evidence linking dietary salt to disease in humans, the potential evolutionary advantage of storing so much salt in the body has not been clear,» says senior study author Jens Titze, who studies the link between sodium metabolism and disease at Vanderbilt University School of Medicine.

Their analysis — which used DNA data from a Neandertal woman from the Altai Mountains in Siberia (SN: 1/25/14, p. 17) and 112,338 present - day British people — confirmed some links between Neandertal heritage and human diseases made by previous studies (SN: 3/5/16, p. 18), but didn't find evidence that Neandertal gene variants contribute to obesity.

Previous studies in humans suggest high - intensity exercise improves motor symptoms, but the evidence wasn't sufficient to determine whether exercise intensity modifies symptoms or disease progression.

Auriel Willette, a researcher in food science and human nutrition at Iowa State University, found evidence that an elevated presence of a protein called neuronal pentraxin - 2 may slow cognitive decline and reduce brain atrophy in people with Alzheimer's disease.

Auriel Willette, a researcher in food science and human nutrition, found evidence that an elevated presence of a protein called neuronal pentraxin - 2 may slow cognitive decline and reduce brain atrophy in people with Alzheimer's disease.

«ELITE provides proof of concept and first direct evidence from human investigation that timing of hormone therapy is imperative for success in the prevention of atherosclerosis progression, the primary underlying pathway that leads to heart disease and stroke,» Hodis added.

In an extensive sleuthing expedition that looked back nearly 20 years, two collaborating research teams contend that they have evidence that xenotropic murine leukemia virus — related virus (XMRV) resulted from the chance recombination of pieces of two mouse viruses in lab experiments and that the connections to human disease are spuriouIn an extensive sleuthing expedition that looked back nearly 20 years, two collaborating research teams contend that they have evidence that xenotropic murine leukemia virus — related virus (XMRV) resulted from the chance recombination of pieces of two mouse viruses in lab experiments and that the connections to human disease are spuriouin lab experiments and that the connections to human disease are spurious.

Working with mouse, fly and human cells and tissue, Johns Hopkins researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center — the nucleus — appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

They searched through 60 years of scientific and newspaper reports to determine two things: first, whether the pathogens cause visible disease symptoms or death in wildlife, and second, whether human outbreaks were preceded or accompanied by evidence of the disease in animals.

Researchers at University of California San Diego School of Medicine have discovered evidence in mice and humans that stomach (gastric) acid suppression alters specific gut bacteria in a way that promotes liver injury and progression of three types of chronic liver disease.

The study, conducted in postmortem human brain cells and in mice, also offers the strongest causal evidence that age - related memory loss and Alzheimer's disease are distinct conditions.

Although amelioration of disease symptoms by interallelic complementation would create an ascertainment bias in the clinic, the lack of evidence concerning interallelic complementation or other biallelic effects in human disease is likely caused by the difficulty in distinguishing such effects from environment and genetic background.

It should be noted, however, that while a study on senescent cell ablation in genetically normal mice would provide at least some evidence on the effect of senescent cells (and their ablation) on promoting cancer, even such a study would likely show less effect than could be anticipated in a large mammal model, since even normally - aging mice rarely suffer metastatic disease to the extent of aging humans, as sheer primary tumor volume is generally sufficient to be fatal to mice.

In the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writIn the article describing the work in Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writin Molecular Therapy, co-authors Charis Himeda, Takako Jones and Peter Jones highlight the important implications for similar types of genetic diseases: «With increasing evidence that the repeat genome (comprising nearly half the human genome) plays important roles in gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they writin gene regulation, additional diseases will likely be found associated with aberrant repetitive genomic sequences,» they write.

• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy • Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study

«In a report published in the journal Lancet, scientists led by Dr. Robert Lanza, chief scientific officer at Advanced Cell Technology, provide the first evidence that stem cells from human embryos can be a safe and effective source of therapies for two types of eye diseases&raquIn a report published in the journal Lancet, scientists led by Dr. Robert Lanza, chief scientific officer at Advanced Cell Technology, provide the first evidence that stem cells from human embryos can be a safe and effective source of therapies for two types of eye diseases&raquin the journal Lancet, scientists led by Dr. Robert Lanza, chief scientific officer at Advanced Cell Technology, provide the first evidence that stem cells from human embryos can be a safe and effective source of therapies for two types of eye diseases»

Earlier in her career, Dr. Lasmézas» research provided the first experimental evidence that the prion disease «mad cow disease» had been transmitted to humans, causing variant Creutzfeldt - Jakob disease.

Kilpatrick is lead author of another paper in this issue on «Conservation of biodiversity as a strategy for improving human health and well - being,» in which he examined the evidence linking biodiversity to disease risk and outlined the steps needed to develop biodiversity conservation into a public health control strategy.

Soy: Due to limited human study, there is not enough evidence to recommend for or against the use of soy in the treatment of kidney diseases, such as chronic renal failure.

«There is evidence that saturated fats cause inflammation in humans and animals, and that is not a good thing because inflammation is an underlying cause of heart disease, obesity, type 2 diabetes, cancer, and dementia,» he says in Eat Fat, Get Thin.

This led to the assumption (which was not based on any experimental evidence in humans) that if saturated fat raises cholesterol, and cholesterol causes heart disease, then saturated fat causes heart disease.

Well, it's «implicated in virtually every known human disease and there is an increasing body of evidence linking free radical production to the process of aging.»

There is INSUFFICIENT EVIDENCE [1,4,5] about the effectiveness of lycopene supplements in the prevention or treatment of age - related macular degeneration (AMD), asthma, atherosclerosis, benign prostate hyperplasia, cancer (brain, breast, cervical, lung, ovarian, pancreatic, prostate), cataracts, coronary heart disease, diabetes type 2, gingivitis, high blood pressure, hot flashes in menopausal women, human papilloma virus (HPV) infection, inflammation, infertility, kidney disease, mouth sores (oral leukoplakia), or as an anticoagulant (blood thinner) or antioxidant or as sun protection.

Our approach to achieving this goal focuses on three objectives: (1) to develop a reliable, predictive panel of biomarkers (including both biological and bio-behavioral measures) that can identify children, youth, and parents showing evidence of toxic stress, and that can be collected in pediatric primary care settings; (2) to conduct basic, animal and human research on critical periods in development and individual differences in stress susceptibility, thereby informing the timing and design of a suite of new interventions that address the roots of stress - related diseases early in the life cycle; and (3) to build a strong, community - based infrastructure through which scientists, practitioners, parents, and community leaders can apply new scientific insights and innovative measures to the development of more effective interventions in the first three postnatal years.

There is currently no evidence that FIV can infect or cause disease in humans.

And there is some evidence that in humans at least, the destructiveness of high phosphorus levels begins quite early in kidney disease.

All of our evidence ties in with research in the human field, and a growing body of veterinary research, which says that vaccines cause allergies, hypersensitivity reactions, autoimmune disease, encephalitis, epilepsy, personality changes and brain damage.

While no studies have been done with this medication in dogs, there have been considerable studies in humans and the evidence is pointing to great success in treatment of cardiac disease with its use.

There is not yet any clear evidence that climate change is affecting the incidence of human vector - borne diseases, in part due to the complexity of these disease systems.

The Global Biodiversity Outlook 4 (CBD 2014), while finding some improvements in temperate and developed parts of the world and the ongoing enlargement of the protected - area estate, also presented evidence of climate - induced effects on biodiversity; the increased spread of diseases and invasive biota; declines in species living in forests, reefs, and many other habitats; and the conversion of ecosystems supporting many kinds of life to ones with singular human uses.

The impact of the full program (prenatal and infancy home visitation) on children's use of alcohol and number of sexual partners is important because recent evidence indicates that alcohol use prior to age 15 years multiplies the risk of alcoholism in adulthood26 and multiple partners increase the risk for sexually transmitted diseases, including human immunodeficiency virus infection.27, 28 The effect of the program on alcohol use is consistent with greater alcohol consumption observed among adult rhesus monkeys who experienced aberrant rearing.29 These findings must be tempered, however, with an acknowledgment of their limitations.