Sentences with phrase «examined gene expression»

In the Joslin study, scientists first examined gene expression in the hypothalamus of a mouse model of insulin - deficient (type 1) diabetes.

A team lead by Dmitri Tkachev of the Babraham Institute in Cambridge, U.K., examined gene expression in frozen sections of the prefrontal cortex of 15 people with schizophrenia, 15 with bipolar disorder, and 15 healthy people.

The researchers also examined gene expression in pre-existing skin biopsies from the same twins to identify possible gene pathways linked to acne.

He examined the gene expression changes in mice well before some of them developed advanced cancers.

Taylor and colleagues made this discovery by exposing fetal mice to BPA during pregnancy and examining gene expression and DNA in the uteruses of female fetuses.

By examining gene expression patterns, the new study found that parrot brains are structured differently than the brains of songbirds and hummingbirds, which also exhibit vocal learning.

This is the first effort to comprehensively examine gene expression, known as the transcriptome, of the adjacent airway field cancerization in NSCLC.

We sought first to examine gene expression in single ES cells isolated directly from specific zones within colonies, with two objectives.

In concurrent studies, the team will examine the gene expression profile of subsets of patients with different clinical outcomes to provide further insight into why certain dogs have more aggressive B - CLL and to identify possible drug targetable pathways to improve the treatment for this cancer.

Not exact matches

They examined whether there were differences in the composition of the breast milks» microRNAs, snippets of RNA that affect gene expression and can be passed to the infant.

Entitled Social science and epigenetics: opportunities and challenges, the symposium will seek to examine how multidisciplinary research into epigenetics — the science of the lasting marks that modify the expression of the genes encoded in our DNA — might help provide answers to societal concerns including why deprivation has such a marked impact on child development and on health outcomes.

Traditional strain - selection techniques are supplemented with strain screening, which can involve examining gene - expression patterns through PCR or understanding global gene expression in relation to environmental factors using gene chips.

They then examined genetic variants throughout the human genome for their effects on gene expression in these two representative populations of immune cells.

In addition, the team examined the relationship between sleep and the expression of a gene in the feather follicles involved in producing dark, melanic feather spots.

The team also recently obtained a grant from the National Medical Research Council in Singapore to pursue a study using the probe to examine the relationship between key Parkinson's disease - linked genes and MAO - B expression and activity to further understand the causes of the disease and illuminate the role of MAO - B in this.

To study gene expression, they then examined RNA sequencing data from 25 of the biliary - phenotype cancers and 44 hepatocellular cancers.

In the new study, a team led by Vanessa Dumeaux during her time at McGill University examined links between gene expression in breast cancer tumors and in the bloodstream.

Using advanced techniques for analyzing the simultaneous expression of genes from multiple organisms in an ecosystem, the scientists examined the roots of willows grown on a polluted site in suburban Montreal.

In this report, Bradamante and colleagues examined endothelial cells in real microgravity aboard the International Space Station and conducted deep gene expression and protein analysis on the cells.

The study examined DNA methylation — an «annotation» of DNA that alters gene expression without changing the genomic sequence itself — in a group of diverse Latino children.

Mao's study examined mitochondria - associated gene expression in the mouse eye tissue and found significant changes in several genes involved in oxidative stress response.

Susana Zanello, Universities Space Research Association scientist at NASA's Johnson Space Center in Houston, examined eye tissue for changes in gene expression in the retina — the sensory tissue at the back of the eye.

They examined the effect of meditation on gene expression patterns in both novice and regular meditators.

We also examined the expression of miR - 7 and KLF4 in brain - metastatic lesions and found that these genes were significantly down - or upregulated, respectively, in the tumor cells in brain.

In particular, they examined what happens during gene expression — when genes copy data from DNA to RNA in order to create proteins.

Gene expression patterns in the hippocampus samples were examined using DNA microarrays that measured the expression levels of over 30,000 genes (transcripts) per sample.

To examine the functional effects of the ACVR1 c. 617G → A; R206H mutation that occurs in classic FOP patients, we compared the activity of wild - type (c. 617G; R206) and mutant (c. 617A; R206H) ACVR1 expression constructs on expression of the BMP pathway transcriptional target gene inhibitors of differentiation 1 (ID1)(29, 30).

In the current study, the researchers used infradian cyclic locomotor activity in the mutant mice as a proxy for mood - associated changes, and examined their molecular basis in the brain by conducting prediction analyses of the gene expression data.

Examining the muscles of insulin - resistant mice, the scientists found similar boost in the expression of those key genes.

To examine trans - regulatory events, the authors plotted matrices of CNA - expression relationships by chromosome (gene location on the Y - axis, CNA location on the X-axis).

Kaur et al. [68] examined selected gene expression patterns in rat retinas from 3 to 14 days after hypoxia.

We are examining the effect of a maximal exercise stress test on gene expression, metabolism, inflammatory markers, and cytokine levels in ME / CFS patients and healthy controls.

Some ~ 20 % of loci examined exhibited cis - regulatory assocations between somatic CNAs and gene expression.

April 2012 - New research: Illuminating embryonic stem cells Collaboration between two EU funded projects «Heroic» and «EuroSyStem», has provided new insights into embryonic stem cells The teams used next generation sequencing technology to examine two key properties of the cells that influence their identity and behaviour: gene expression and gene regulation.

Inspired by the knowledge - based analysis methods developed for gene expression data analysis, we implemented methods for examining functionally - related SNPs as a group.

In collaboration with Margarita Salas (CBM - CSIC), in bacteriophage φ29 we examine the transcriptional regulator p4 that functions as a switch between early and late gene expression during the infection cycle.

Elowitz's team is now examining the role stochastic gene expression plays in stem cells, undifferentiated cells that give rise to the different tissues in our bodies.

Since the unrelated NGT subjects have a broad BMI range, we further examined the impact of obesity on the expression of these six genes by comparing nonobese and obese NGT subjects.

To study the effects of LRO - related gene mutations, Dr. Huizing is performing fluorescent protein expression studies using patients» cells in order to examine defective intracellular trafficking.

During this time the field of «nutrigenomics» emerged, which examines the relationship between food and gene expression.

To evaluate whether altered expression of the ABL genes is associated with breast cancer progression and metastasis, we examined the expression of ABL1 and ABL2 in normal and invasive breast tumor specimens using published TCGA (The Cancer Genome Atlas) data sets (14 — 16).

She will determine which cells harbor the most latent and productive HIV and examine the cells» total gene expression to determine how the gut microenvironment contributes to their long - term survival.

The expression of germ cell marker genes in monkey ES cells and tissues was examined using an RT - PCR analysis.

Among the early germ cell markers examined, VASA is a candidate gene for detecting pre-meiotic germ cell differentiation from monkey ES cells, because its expression is detected earlier in the primordial stage of germ cell development in comparison to that of PIWI family genes in vivo in mice and humans [11], [36]--[38], [49].

We are also examining how gene expression and mitochondrial function is altered in human cells in the disorder known as Chronic Fatigue Syndrome or Myalgic Encephalomyelitis, in order to develop objective tests for the illness as well to identify causal factors.

The expression of DAZL, VASA, and the PIWI family genes was detected in the testis, but not in the somatic tissues examined.

Thus for every PrEn marker examined we found subtle increases in gene expression were detected when the V − S + and V+S + fractions were compared and that these then translated into more robust increases in the V+S − fraction.

To explore the differentiation markers for detecting germ cells differentiated from ES cells, the expression of various germ cell marker genes was examined in tissues and ES cells of the cynomolgus monkey (Macaca fascicularis).

(A) The expression patterns of germ cell marker genes in monkey testis (5 years old), mouse embryonic fibroblast (MEF), monkey ES cells (ES), and developing EBs (days 3, 7, 14, 21, and 28) were examined using an RT - PCR analysis.

The only clue indicating that differences in gene expression level are not the reason for the observed correlation between the recombination rate and the size of introns is that we do not see a comparable pattern when examining the size of exons, the number of exons per gene, and the overall size of proteins.