The team
examined three forms of retinal degenerative diseases,
rod cone dysplasia 1 being the most severe, or earliest onset, followed by X-linked progressive retinal atrophy 2
and then early retinal degeneration.
To further
examine the morphology of cells
and the localization of protein expression within the retina, immunohistochemical staining of both paraffin
and OCT retinal sections was performed with the following antibodies (Table S1): human
cone arrestin (for
cone photoreceptors), rhodopsin (for
rod photoreceptors), RPE65 (for the retinal pigment epithelium, RPE), glial fibrillary acidic protein (GFAP, for astrocytes
and Müller cells), glutamine synthetase (for Müller cells)
and G0alpha (for ON bipolar cells).