Sentences with phrase «examined tumor tissue»

When researchers at Johns Hopkins University in Baltimore, Maryland, examined tumor tissue from the original man with colon cancer who responded to a PD - 1 inhibitor, they found a clue: His tumor had mutations in «mismatch repair» genes, so - called because their encoded proteins fix errors in DNA bases when cells replicate their DNA.

Whereas traditional stratification is based on examining the tumor tissue, cancer medicine is rapidly moving toward stratification based on the tumor's molecular makeup.

Sometimes, after examining tumor tissue, the tumor is diagnosed as a metastatic brain tumor but the patient has no history of cancer.

Not exact matches

This pilot research builds on an earlier study by Milovancev and collaborators that examined the ability of MRIs and CT angiograms to detect cancerous lesions related to FISS, and another study that looked at three methods for assessing margins for canine mast cell tumors and soft tissue sarcomas.

To determine local immune control, where the invasive tissue interfaces with normal cells, post-birth placentas and stage - four melanoma tumors were examined.

We were in the CT scanner room, where I was examining tissue extracted from a tumor in a young woman's chest.

Various genetic testing methods were used to examine lung tumors, uninvolved lung tissue and normal - appearing airways located varying distances from the tumors.

On average, the pancreatic cancer patients examined in the study carried 15 LINE - 1 insertions in their tumor DNA that were not in healthy tissue.

Furthermore, we examined the expression of KLF4 in brain metastatic tissues by immunohistochemistry and found that KLF4 was expressed more in the nucleus and significantly less in cytosol in brain metastatic tissues compared with primary tumors (Fig. 6C and D).

«To our knowledge, this is the first naked RNA nanoparticles to have been comprehensively examined pharmacologically in vivo and demonstrated to be safe, as well as deliver itself to tumor tissues by a specific targeting mechanism,» he says.

Dr. Jain is regarded as a trailblazer in the study of tumor microenvironment, examining in detail the notion that the relationships between tumors and their surrounding non-tumor tissue — including blood vessels — are essential determinants of disease progression, therapeutic efficacy, and patient prognosis.

Examining expression levels of H2AX in breast cancer tumor data from The Cancer Genome Atlas, a large National Institutes of Health database containing genetic information about tumor tissue from more than 11,000 patients, the Roswell Park team found that breast cancer patients whose tumors had high levels of H2AX had a significantly worse prognosis than those with low levels.

When the team first examined the microbial composition of intestinal biopsies, they saw the bacterial strains in the tumors and surrounding tissues of colon cancer patients differed from the bacterial strains in the gut of healthy individuals.

The pathologist examining the biopsy tissue uses different cellular criteria of malignancy to grade the tumor as Grade I, Grade II, or Grade III.

Cells from the biopsy tissue are then examined under the microscope and the tumor is assessed as high grade (aggressive), intermediate, or low - grade (slow - growing).