Sentences with phrase «examining gene activity»

After killing the animals they examined gene activity in the hypothalamus, the brain's «reward» centre.

Not exact matches

Epigenetics (literally «above the gene») is a recent scientific development that examines how particular mechanisms can influence whether certain genes are turned off, turned on, or modify a gene's level of activity.

The team also recently obtained a grant from the National Medical Research Council in Singapore to pursue a study using the probe to examine the relationship between key Parkinson's disease - linked genes and MAO - B expression and activity to further understand the causes of the disease and illuminate the role of MAO - B in this.

To start, the scientists examined previous experiments and identified several transcription factors — managerial proteins that switch on the activity of large sets of genes — that seemed crucial to the ability of immature neurons to develop into adult sensory neurons.

To that end, they examined in mouse embryos the global distribution of an epigenetic mark known to play a critical role in regulating the activity of genes.

Thus, the researchers examined the list of genes used for the successful prediction of locomotor activity.

To determine whether the FLRG transgene was causing increased muscle growth by blocking myostatin activity, I examined the effect of combining the FLRG transgene with a loss - of - function mutation in the myostatin gene.

To examine the functional effects of the ACVR1 c. 617G → A; R206H mutation that occurs in classic FOP patients, we compared the activity of wild - type (c. 617G; R206) and mutant (c. 617A; R206H) ACVR1 expression constructs on expression of the BMP pathway transcriptional target gene inhibitors of differentiation 1 (ID1)(29, 30).

In the current study, the researchers used infradian cyclic locomotor activity in the mutant mice as a proxy for mood - associated changes, and examined their molecular basis in the brain by conducting prediction analyses of the gene expression data.

Furthermore, we are testing candidate tissue specific genes using models described in the projects listed below to examine various nutrient responses including fat metabolism, physical activity, intestinal permeability, calcification and aging.

Hoping to develop a treatment that works more broadly across diseases, a Penn Vet team used canine disease models to closely examine how retinal gene activity varied during the progression of three different forms of inherited vision disease.

Eight HARs showed differences in their enhancer activity when the human mutations were present.4 These differences modify how genes were expressed in the developing limb (HAR2, 2xHAR114), eye (HAR25), and central nervous system (2xHAR142, 2xHAR238, 2xHAR164, 2xHAR170, ANC516 / HARE5).4, 10 Because relatively few time points have been examined, it is likely that an even higher percentage of the tested HARs are active enhancers at some point during embryonic development or in adult tissues, possibly with human - chimp differences.

The adult offspring of high compared to low maternal care mothers show epigenetic changes in promoters, exons, and gene ends associated with higher transcriptional activity across many genes within the locus examined.