Sentences with phrase «excessive lung inflammation»

This strain showed a highly virulent phenotype, with rapid multiplication during the early stage of infection in a murine model of TB with excessive lung inflammation, and infection with this strain resulted in more rapid death of mice than infection with the reference H37Rv strain.

Not exact matches

«What we saw in mice lacking STIM1 — whose T - cells can not generate calcium signals — is that the number of mycobacteria in their lungs was dramatically increased, resulting in excessive inflammation,» says Stefan Feske, MD, an associate professor of pathology at NYU Langone and the study's senior author.

In lungs lacking a «halt» signal from regulatory T cells, (right) killer T cells and other pathogen fighters accumulate (purple rings) in an excessive immune system response, creating lung inflammation and asthma - like symptoms.