It is triggered by the immune system, and new insights into immune processes have thrown up a number of
exciting drug targets.
This makes
it an exciting drug target, but until now, it has been difficult to test the effectiveness of potential new drugs on blocking the protein.
«Our findings have provided us not only with a new perspective on the role of astrocytes in cognition, but also with
an exciting drug target to enhance memory and maybe even stave off memory decline in Alzheimer's disease,» says senior author Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease and professor of neurology and neuroscience at the University of California, San Francisco.
Not exact matches
More importantly, it opens up
exciting avenues of research to explore how restoration of p53 with
drugs such as those that
target ERAP1 can help to harness the immune system to recognise and destroy cancer cells.»
So it's extremely
exciting to apply the technology to research directed at identifying
drug targets to help people suffering from a specific disease.»
One of the most
exciting recent advances in clinical cancer research was the discovery that this subgroup of patients respond — sometimes dramatically — to a new class of
drugs targeting the MAPK pathway through which BRAF signals.
«The fact that we can
target one cell type in one tissue using an existing
drug makes us
excited about the possibilities of testing this in patients.»
«These
exciting results provide new hope for developing
drugs against an important molecular
target in the brain,» said Roderick Corriveau, program director at the National Institute of Neurological Disorders and Stroke, which helped support the research.
«This is very
exciting because we haven't had a new
drug for stroke in decades, and this suggests a
target for such a
drug,» says lead author Dr. Zsuzsanna Fabry, professor of pathology and laboratory medicine.
«We are
excited about our results because there are
drugs that exist that specifically
target Akt in cancer.
«Following the
exciting discovery that dengue virus NS1 protein can directly cause vascular leak, the hallmark of severe dengue disease, we have now succeeded in disentangling the mechanisms responsible, suggesting new
drug targets for inhibiting severe dengue,» says Dr. Eva Harris, the senior investigator.
It may provide an
exciting additional
target for further gene and
drug discovery.
This is a particularly
exciting prospect, as it could point the way towards
drug targets and the development of broadly applicable new therapeutics that could work to counteract inherited weaknesses in the joints.
«One
exciting thing about this finding is that the GDP - bound form of these signaling proteins is typically much easier to
target with a
drug,» Shokat said.
The researchers are also very
excited about how this could be used in electronics that are ingested from
targeted drug delivery devices to diagnostic devices that can make their way through the gastrointestinal system without causing harm.