That lung disease
exhibited the characteristics of a Th2 - type immunopathology with eosinophils in the lung sections suggesting
hypersensitivity that was reminiscent of the descriptions of the Th2 - type immunopathologic
reaction in young children given an inactivated RSV vaccine and subsequently infected with naturally - occurring RSV [32]--[33].
This experiment was conducted to verify the findings in the initial experiment of a
hypersensitivity immunopathologic - like
reaction after SARS - CoV challenge of vaccinated animals, to determine if a higher dosage of the S protein vaccine (SV) would suppress infection and still
exhibit a similar
reaction, and whether the original β propiolactone inactivated whole virus vaccine (BPV) that had shown an immunopathologic - like
reaction after challenge of vaccinated ferrets and nonhuman primates
exhibited a similar immunopathologic
reaction in the mouse model [13], [14].