The aim of this study was to perform a segregation analysis in order to assess the possible
existence of major genes affecting hip and / or elbow dysplasia in four Finnish dog populations.
If any analyses of the five shuffled data sets did not give similar estimates of a major gene as the analyses from the original data, H0 was rejected, and
the existence of a major gene was considered as likely.
The existence of a major gene was considered likely for hip dysplasia in all the breeds and for elbow dysplasia in one breed.
An effect of a major gene genotype was added to the polygenic models to analyse
the existence of a major gene.
Previously, a possibility of
the existence of a major gene for hip dysplasia has been reported in the German Shepherd Dog and the Labrador Retriever (Leighton, 1997).
The aim of the study was to assess the possible
existence of major genes influencing hip and elbow dysplasia in four dog populations.
Not exact matches
The
existence of segregating
major genes was preliminarily assessed based on frequency distributions
of hip and elbow dysplasia in the offspring
of individual sires.
Acquiring more reliable information about the
existence of the possible
major genes would require, for example, a planned mating or crossing experiment between suitable parents or breeds.