Sentences with phrase «existing animal models»

Such animals would be better than existing animal models for testing potential new treatments, he suggests.

Not exact matches

One 2014 study based on modeling animal movement found that increasing vehicle density on existing roads, rather than adding more roads with lower density, resulted in fewer wildlife fatalities.

«Whether an insulating effect of obesity exists is of significance both for humans and for animal models of obesity,» the research team wrote.

A fourth study highlights possible interactions of CBD with existing anti-epileptic drugs (AEDs) in animal models of seizures.

They go on to suggest that «lowering levels of TNF may be an effective strategy in improving host defense against S. pneumoniae in older adults,» and that, «although it may be counterintuitive to limit inflammatory responses during a bacterial infection, [some existing] clinical observations and our animal model indicate that anti-bacterial strategies need to be tailored to the age of the host.»

Organoids are especially useful because no great animal models for CF exist, Kerem says; ferrets and pigs are sometimes used, but «they are expensive and not available to most researchers.»

In addition, «since no animal models of fibromyalgia exist, our model provides a much - needed tool for understanding what makes current fibromyalgia drugs efficacious and for finding more effective drugs,» the researchers wrote.

Because M. lepromatosis can not be grown in the lab and animal models for this version of leprosy do not exist yet, the scientists used an infected skin sample from a patient in Mexico to obtain the bacterium's genetic material.

Genetic modification in zebrafish models is cheap and easy, so authors point out that future research on these animal models will contribute to understand the molecular relationship that exists between the proteins involved in the physiopathology of megalencephalic leukoencephalopathy.

«By using an animal model to expand tumor cells recently removed from patients, we hoped to re-create more closely what actually happens in patients with pancreatic cancer rather than by using existing artificial cell lines,» said Wei Zhang, Ph.D., an endowed Hanes and Willis Family Professor in cancer at Wake Forest School of Medicine, a part of Wake Forest Baptist, and principal investigator of the study.

They may be used to understand normal or abnormal structure and function or determine the efficacy of treatments where no other suitable animal models exist.

We developed several computational and machine learning methods to successfully identify behavioral patterns or signatures associated with different classes of reference drugs, from which to predict the class of novel compounds (Brunner et al., 2012, Alexandrov et al., 2015), and more recently developed methods to allow us to compare animal models of AD and its progression, and to identify (in silico) novel compounds from our existing database of thousands of novel and reference compounds with the potential to reverse the AD model behavioral profile.

Current work focuses on identifying novel Eph receptor - targeting agents (such as peptides and small molecules) as well as improving the existing ones in collaboration with medicinal chemists and structural biologists, and evaluating them in cell culture and in vivo animal models.

Towards that goal, the Foundation invested heavily in essential drug discovery assets like animal models and in vitro systems to screen existing drugs and compound libraries.

And, as much as vegans wouldn't want to admit it, if the human species returned to a more literal Paleo picture — actually hunting for actual wild animals when necessary (and eating them fresh), making animal foods just a part of the overall diet, and eating no refined plants (like white flour or white rice, which don't exist in nature), a couple things would happen: (1) we could put an end to the horrific treatment of animals in the factory farming industry, and (2) the environmental devastation that results from our current food production model would be substantially minimized.

Further studies in animal models continued to demonstrate curcumin's remarkable ability to prevent the formation of malformed proteins and significantly improve the body's ability to break down existing build - up in the brain.

This is a detailed 5 week plan for a series of Year 1 Design and Technology lessons in which they will investigate and evaluate existing models, then design, make and evaluate their own animal enclosures.

Many regard the Calgary model as the future of municipal animal services operations, but getting there for most American cities will require turning the existing animal control paradigm that presides in the U.S. on» its head.

Opportunities for collaboration with researchers in other disciplines also exist and may involve advising on selection, development, and refinement of animal models and animal biomethodology.

Although no studies have yet examined whether maternal relationship quality during pregnancy is linked to the risk of infectious disease in the offspring, there is growing evidence from animal models that a link exists between prenatal maternal stress and a wide range of adverse health outcomes in the offspring, including immune dysfunction and infectious diseases [14,15].