Congressional members, leaders at the National Institutes of Health, and a variety of patient groups have expressed increasing dissatisfaction with the president's policy as the limitations of
existing cell lines — 22 of which are available — have become clear.
CAMR was founded around when President George W. Bush issued an executive order on 9 August 2001 limiting federal funding for hESC studies to
existing cell lines.
In one promising approach, cellular reprogramming, stem cells can be generated by fusing adult skin cells with embryonic stem cells from
existing cell lines.
Not exact matches
In August of last year, President Bush approved the use of federal funds to support research on a limited number of
existing human embryonic stem
cell lines.
Although he never banned this research outright, President Bush limited federal funding for research to the embryonic stem
cell lines that
existed before August 2001, thus drawing a
line at destroying human embryos created after that date.
It was done by dividing an
existing interior shell into five single -
cell slice
lines.
He ruled that work on
existing embryonic stem
cell lines derived outside federally funded labs did not violate a ban on the destruction of embryos.
The scientists also generated a panel of (reconstructed) ancestral and
existing TRIM5 genes (19 total), expressed them in cultured
cell lines, and exposed the
cells to 16 different retroviruses (lentiviruses and others) to see which TRIM5 versions conferred resistance to which viruses.
In these instances, the committee says, the use of
existing embryonic
cell lines derived from embryos fewer than 14 days old should be considered before resorting to the use of
cells taken from surplus in vitro fertilization embryos fewer than 14 days old.
Where permitted, ES
cells should be drawn from sources in the following order: (1)
existing ES
cell lines, originating from ES
cells derived from embryos less than 14 days old; and (2) surplus human embryos less than 14 days old that were created for fertility treatment.
In yesterday's order, Lamberth wrote that they did not: «The prior [Bush Administration] guidelines, of course, allowed research only on
existing stem
cell lines, foreclosing additional destruction of embryos.»
Existing internet infrastructure typically uses different physical components for different services:
cell towers for 3G and 4G, cable or phone
lines for home broadband.
In September Harvard University scientists reported using
existing stem
cell lines — not eggs — to create more stem
cells.
Cell lines from human tumours did
exist, but were considered unsafe: what if cancerous
cells were transferred along with the vaccine?
In 2001, after President Bush limited federally funded research to 69
existing embryonic stem
cell lines, Melton launched a private fund - raising crusade and developed 17 new
lines that are now available to any reputable stem
cell researcher.
Their research showed that primordial follicles are highly stable, and that germ -
line stem
cell activity can not be detected, even in response to the death of half the
existing follicles.
While American stem
cell researchers were celebrating the final NIH stem
cell guidelines, questions remain, particularly whether the National Institutes of Health will approve
existing lines in time for use with stimulus funds.
Stem
cell advocates have been expressing serious worry that ethical requirements spelled out in the draft guidelines — in particular, informed consent procedures for embryo donors — will rule out the use of many
existing human embryonic stem
cell lines, including the 21
lines approved under the Bush Administration.
Importantly, researchers must still study
existing embryonic stem
cell lines — the gold standard — to rule out any hidden risks in the lab - made
cells, he says.
However, some experts warn that it's far from clear how many holders of
existing hES
cell lines will be willing to relinquish even partial control of one of biomedicine's hottest commodities.
In addition, the bank «will actively recruit» the holders of
existing hES
cell lines around the world to deposit their
cells, Radda says, and will work out intellectual property agreements with
cell donors on a case - by - case basis.
But instead of prodding extracted B
cells to proliferate, Wilson says, the teams simply plucked the antibody - producing genes from them and inserted those into
existing B -
cell lines, thereby increasing their protein output.
Knowing more about the activation process has led researchers to be able to induce greater vulnerability by cancer
cells to an
existing first -
line treatment for cancers (mainly lung) driven by a receptor called EGFR.
Cell lines are therefore indispensable in medical research and a large number of cell lines exist that originate from many different tumor ty
Cell lines are therefore indispensable in medical research and a large number of
cell lines exist that originate from many different tumor ty
cell lines exist that originate from many different tumor types.
Tensions have escalated since August 2001, when President George W. Bush limited publicly funded research on embryonic stem
cells to already
existing lines.
In August of last year, President George W. Bush announced that scientists who received public research money could use only the human embryonic stem -
cell lines that already
exist — a decision that dismayed many researchers.
The only stem
cell research he would permit, Bush said, was research using
existing embryonic
lines as well as so - called adult stem
cells, which occur in anyone of any age.
The researchers tested several
existing cancer drugs on the mutated
cell lines.
Last week, Roe Jung - hye announced that an internal investigation found that Hwang had deliberately falsified data in the May paper and that only two stem
cell lines existed out of the 11 cited.
«By using an animal model to expand tumor
cells recently removed from patients, we hoped to re-create more closely what actually happens in patients with pancreatic cancer rather than by using
existing artificial
cell lines,» said Wei Zhang, Ph.D., an endowed Hanes and Willis Family Professor in cancer at Wake Forest School of Medicine, a part of Wake Forest Baptist, and principal investigator of the study.
Such an immunological exemption could alleviate many concerns about using
cells for therapy that don't exactly match the recipient's immune system - such as
existing embryonic stem
cell lines that are not directly derived from the recipient.
The MMRRC
exists to serve the research community by preserving and distributing biomedically valuable mouse strains and mutagenated
cell line collections.
Organized by the South Dakotans for Lifesaving Cures, the petition drive comes eight months after President Barack Obama overturned a 2001 order by then - President George W. Bush that barred the National Institutes of Health from funding embryonic stem
cell research beyond the
existing stem
cell lines.
The order severely restricts embryonic stem
cell research to
existing lines of
cells and bans federal funding for any research expansion outside his directive.
Current policy only allows federal monies to be used for research on 21 stem
cell lines that
existed before 2001.
I don't know that a 12 % glycolic would really be enough to minimize already
existing lines and wrinkles, but by increasing
cell turnover you would definitely be preventing more
lines and wrinkles with it.
The
existing land
line telephone system, its infrastructure, regulations, the entire industrial halo of the telephone corporations (a near monopoly, despite the failed trust busting attempt of an earlier era) stifled and constrained North American mobile phone adoption, short - sighted governments taxed infant
cell companies rather than freeing them of the uphill struggle they faced, and as a result, the average North American is backwards compared to the average denizen of an emerging economy when it comes to mobile life.