The DNA vital to the life of a cell is packaged in chromosomes, and a variety of checkpoints, repair
mechanisms, and other
cellular safeguards
exist to maintain the integrity of the chromosomes during cell growth and division.
To achieve this goal, the center's clinical and basic investigators are engaging in four distinct yet synergistic projects: 1) identifying
mechanisms of abnormal cell proliferation, 2) examining the role of thrombosis in the development of PAH, 3) studying the role of nitric oxide deficiency in PAH, and 4) testing two
existing drugs to restore lost
cellular function due to a genetic mutation related to PAH.