Others were similar to
existing resistance genes, but not precisely the same.
Not exact matches
The scientists also generated a panel of (reconstructed) ancestral and
existing TRIM5
genes (19 total), expressed them in cultured cell lines, and exposed the cells to 16 different retroviruses (lentiviruses and others) to see which TRIM5 versions conferred
resistance to which viruses.
Genes that code for
resistance to antibiotics
existed even before we discovered and started using antibiotics.
The
gene, called the Pm3
resistance gene,
exists in different variations, so called alleles.
The study demonstrates that the evolution of
resistance will likely be a severe roadblock for
existing CRISPR
gene drive approaches, which must be addressed before scientists could successfully employ them in the wild.
These
genes exist on plasmids, small segments of DNA that are capable of moving from one bacterium to another, potentially spreading antibiotic
resistance to other bacterial species.