Sentences with phrase «exosomes containing»
Kraig and his team, which includes Aya Pusic and Kae Pusic, PhD, discovered that dendritic cells, professional antigen presenting cells of the immune system, can be stimulated by factors released during environmental enrichment to produce exosomes containing microRNAs that improve brain health.
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According to the head of the research group of chemoresistance and Predictors of tumor response and stromal environment ICO - IDIBELL, Alberto Villanueva, «tumor exosomes contain certain proteins (Dicer, TRBP and Ago2) able to process microRNAs that can alter the around the tumor cells transforming them into tumoral cells.»
The biomedical engineers also showed that the exosomes contain miRNAs — tiny pieces of RNA that regulate cell behavior and are known to play a role in neuronal differentiation.
They revealed that many of these exosomes contained ephrins and Ephs, and decoded the cellular mechanism by which they were packed into the exosomes.
These exosomes contain specific microRNAs that promote myelination of aging brain as well as brain damaged by multiple sclerosis modeled in animal brain tissues.
Not exact matches
Because we've been working with exosomes for years, we can reliably and reproducibly isolate exosomes from almost any biofluid — from plasma and tissue culture media to cerebrospinal fluid, synovial fluid, and even mouse bronchial alveolar fluid (which does not contain many exosomes).
Exosomes are small vesicles which are secreted by all cells and contain proteins and messenger RNAs and microRNAs.
Researchers at the Bellvitge Biomedical Research Institute of Bellvitge, the Catalan Institute of Oncology and the University Hospital of Bellvitge have participated in an international study published in the journal Cancer Cell that describes how exosomes secreted by tumor cells contain protein and microRNA molecules capable of transform neighboring cells into tumoral cells promoting tumor growth.
The plasma containing magnetic beads then flows through the microchannels on the diagnostic chip in which the beads can be readily collected using a magnet to extract circulating exosomes from the plasma.»
We have found that exosomes and the cargo they contain are crucial mediators of stem cell - based heart regeneration, and we believe this might lead to an even more refined therapy using the «active ingredient» instead of the entire stem cell,» said Eduardo Marbán, MD, PhD, director of the Cedars - Sinai Heart Institute and a pioneer in developing investigational cardiac stem cell treatments.
«The exosomes appear to contain the signaling information needed to regenerate healthy heart tissue, they are naturally able to permeate cells, and they have a coating that protects their payloads from degradation as they shuttle from cell to cell,» said Marbán, senior author of an article in the May 6, 2014 Stem Cell Reports.
Exosomes and other extracellular vesicles (EVs) are small membrane vesicles containing protein, messenger RNA, microRNA, DNA, and lipids, which are secreted by various cells and are stable in body fluids including blood, saliva, urine, cerebrospinal fluid, and breast milk.
In a paper published Feb. 19 in Nature Cell Biology, the scientists show that a cutting - edge technique called asymmetric flow field - flow fractionation (AF4) can efficiently sort nano - sized particles, called exosomes, that are secreted by cancer cells and contain DNA, RNA, fats and proteins.
«Our results show that not only do exosomes enhance the phenomenon of the «Warburg effect» in tumors, but exosomes also contain «off - the - shelf» metabolites within their cargo that cancer cells use directly in their metabolic processes,» Zhao said.
We will examine the characteristics of the RNA contained in exosomes in the aqueous humor with special emphasis on its function in exfoliation glaucoma, including the most common form of secondary open - angle glaucoma.
The Kraig lab will investigate the underlying biological mechanisms and functions of the extracellular microRNAs contained in stimulated dendritic cell - derived exosomes.
The droplets, called exosomes, contain genetic information that can be analyzed to determine a cancer's molecular composition, even how far it has advanced.