Further study is needed to gain a better understanding about whether
exosomes entering cells via macropinocytosis have other features that could enhance their anti-tumor capabilities.»
In this way, the mechanism by which
exosomes enter cells resembles the spread of viral infections,» says Helena Christianson, doctoral student in Belting's research team and first author of the study.
Not exact matches
The team showed that
exosomes could serve as an efficient carrier of RNAi, given that these nano - sized vesicles easily travel across the body and
enter cells, including cancer cells.
«The increased number of
exosomes reaching the pancreas may gain further advantage to
enter KRAS - associated cancer cells as a result of enhanced macropinocytosis, which concurs with previous findings,» said Kamerkar.