Sentences with phrase «expansion of copy number»

Gerton hypothesized that cancer cells, which are highly proliferative and might need more than the usual amount of ribosomes, would select for expansion of copy number.

«We thought pressure to proliferate would lead to expansion of copy number, so there would be more DNA transcribed into RNA.

Not exact matches

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

Enhanced starch digestion through extreme AMY2B copy number expansion has been postulated to be an adaptation to the shift from the carnivorous diet of wolves to the starch - rich diet of domesticated dogs30.

Although none of the German Neolithic samples carries the copy number expansion of the AMY2B gene associated with starch digestion, we find that this gene is present in three copies in NGD, though this is due to a large segmental duplication that is shared with multiple modern dogs, an event separate from the tandem AMY2B duplications.

The absence of the extreme AMY2B copy number increase in these ancient samples indicates that the selective sweep associated with AMY2B expansion must have occurred well after the advent of agriculture and the Neolithic in Europe.

This is consistent with recent findings that AMY2B copy number is highest in modern dog populations originating from geographic regions with prehistoric agrarian societies, and lowest from regions where humans did not rely on agriculture for subsistence34 and supports the claim that the expansion occurred after initial domestication (possibly after the migration of dingoes to Australia 3,500 — 5,000 years ago) 34.

In this work we use high - resolution analysis of copy number, and analysis of segregation in trios, to define new, independent allelic series of amylase CNVs in sub-Saharan Africans, including a series of higher - order expansions of a unit consisting of one copy each of AMY1, AMY2A and AMY2B.

Getting hold of a copy of F - Zero X Expansion Kit is tricky, due to it only ever being released in Japan and in relatively small numbers.

However, this number is absolutely dwarfed by Red Dead Redemption, which has sold nine million copies since its release in May 2010 along with another two million copies of the Undead Nightmare expansion disc.