Sentences with phrase «experimental cell system»
Unfortunately, he said, there had not been an experimental cell system that researchers could manipulate to explore that circuitry.
http://www.hhmi.org/ Not exact matches
The experimental drug, according to reports, sharply reduced the cell - killing protein in the subjects» nervous systems and apparently had no major side effects.
Using the mouse as an experimental model, LMU neurobiologist PD Dr. Conny Kopp - Scheinpflug and her research group have now demonstrated that the activity of nerve cells in the auditory system has a direct effect on myelinization — higher levels of activity correlate with the formation of thicker myelin sheaths.
Using shadows rather than light, researchers developed an experimental system for imaging cells that attaches to a cell phone and sends the data to diagnostic centers.
The idea that tensegrity dictates the shape and organization of living cells was initially controversial, but as a result of experimental validation in multiple systems, it has gained greater acceptance over time.
Next, the team tested the GD2 CAR - T cells in mice whose brainstem was implanted with human DIPG tumors, an experimental system that Monje's lab pioneered.
Systems biologist Prof. Thomas Höfer and colleagues (also of the DKFZ) performed mathematical analysis of these experimental data to provide additional insight into blood stem cell dynamics.
«Right now,» Wells said,» we're hypothesizing that the mechanical interactions modeled by the Shenoy lab explain aspects of cancer and fibrosis, and we're developing the experimental systems to confirm it with real cells.»
The study included 124 newly diagnosed patients at 25 clinical trial sites in the U.S. Two - thirds of the patients were treated with ICT - 107, an experimental vaccine based on immune system cells called dendritic cells that were exposed to six synthetic proteins, or antigens, known to be involved in GBM development.
In the new study, published in the Journal of Experimental Medicine, the scientists found that it is also involved in how cells in the immune system develop with age.
We describe an experimental model system that definitively links surgery and the subsequent wound - healing response to the outgrowth of tumor cells at distant anatomical sites.
To better understand this process, the researchers created an experimental system in which they induced, in a controlled fashion, breaks in the DNA of different chromosomes in living cells.
«But the unique developmental potential of a zygote, formed right after the sperm and egg meet, is very, very difficult to study, due to limited materials and the lack of a cell - culture experimental system.»
These experimental systems allow scientists to dissect key molecular pathways that specify cell fate decisions in embryonic development,» said team leader Lin He, a UC Berkeley associate professor of molecular and cell biology.
The similarities of J - Lat cells to latently infected CD4 + T cells have established the utility of this experimental system for identifying and characterizing mechanisms of HIV - 1 latency.
Rothman had proposed that one of the proteins necessary for his experimental system and for fusion in live yeast cells, NSF, attaches to the membrane through a second protein and its as - yet - unidentified collaborators.
The goal is to not only provide broadly applicable experimental tools but also help transform the way in which we think about single cells, cell - cell interactions, diseased cellular states and therapeutics so as to create a new paradigm for understanding and designing systems - level cellular behaviors in multicellular organisms.
Single - cell technologies will be applied to experimental model systems such as organoids, miniature organs grown in the petri dish from one or more cells.
An instructive model of EMT is based on an experimental system employing normal primary human mammary epithelial cells (HMECs).
Experimental data have indicated that RyR1 is also expressed in some areas of the central nervous system, in some cell types of the immune system and in smooth muscle cells.
Previosly in a preclinical study BRAF inhibitor - resistant mutated BRAF melanoma cells were developed as an experimental model system to mimic BRAF inhibitor - resistant melanoma patients and to study the mechanisms of resistance.
This two - volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system.
As the effects of these tools are likely cell type - and context - dependent, it may make sense to try multiple CRISPR tools when setting up your experimental system.
To study blood development, researchers typically purify blood stem cells from the bone marrow of mice and transplant them into mice exposed to radiation, thus creating a tractable experimental system.
Our favorite experimental system is the Xenopus egg extract system for studies on cell cycle progression and regulation, microtubule dynamics, spindle assembly and chromosome behaviour (Karsenti and Vernos, 2001).
PEC - 01 cells contained within the Encaptra ™ drug delivery system, a semi-permeable encapsulation device, together comprise an experimental treatment known as the VC - 01 ™ combination product.
About the «Human Emulation System» Powered by Organs - On - Chips Technology Based on the Organs - on - Chips technology, Emulate has created a new living Human Emulation System ™ that provides a real - time window into the inner workings of human biology and disease — offering researchers a new technology designed to predict human response with greater precision and detail than today's cell culture or animal - based experimental testing.
For type 1 diabetes, there are a number of experimental approaches being taken to curb the immune system's attack on the beta cells.
This experimental treatment for type 1 diabetes combines the Encaptra ™ drug delivery system, which is a semi-permeable pouch, and PEC - 01 ™ cells, pancreatic precursor cells derived from human embryonic stem cells.
Shaorong Deng gets an experimental treatment for cancer of the esophagus that uses his own immune system cells.
With FIDO operational, Guy worked on a number of different projects, including research on the efficiency of fuel cells, research on German aviation fuel as inferred from the spectrographic analysis of aircraft exhaust, not to mention the design and testing of fuel baffles, experimental forest - clearing devices, and fuel propellant systems (including flamethrowers — an application the pacifically - minded Guy must have disliked.)