Sentences with phrase «experimental colitis»

Neurath MF, Fuss I, Pasparakis M, Alexopoulou L, Haralambous S, Meyer zum Büschenfelde KH, Strober W, Kollias G. 1997, «Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice» Eur.

Dietary medium - chain triglycerides prevent chemically induced experimental colitis in rats: Medium chain triglycerides show promise for nutritional therapy of inflammatory bowel disease (e.g., Crohn's disease and colitis) as an anti-inflammatory nutrient in the colon.

Using experimental colitis mouse models that resemble different aspects of human IBD, we have been investigating the processes and molecules responsible for causing severe inflammation in the digestive tract.

For example, animal studies have demonstrated that the expression of P - glycoprotein, a broad - specificity transmembrane transporter on intestinal enterocytes, is induced by breast milk (and not formula exposure) and is protective against experimental colitis (3).

More recently, another HDAC inhibitor, ITF2357, was shown to modulate IL - 6 — dependent CD4 + T cell polarization into Th17 cells through targeting the IL - 6 / STAT3 / IL -17 pathway, and it reduced the severity of experimental colitis (49).

In two other studies that assessed the therapeutic effect of VPA on experimental colitis or experimental autoimmune encephalomyelitis, the investigators showed that VPA was effective and safe up to 400 mg / kg / d (28, 29).

Pelvic organ cross-sensitization to enhance bladder and urethral pain behaviors in rats with experimental colitis.

For example, in rats where experimental colitis (colon irritation) was induced, many of the rats also experienced bladder and urethral pain (Yoshikawa et al., 2015).

Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation - related tissue destruction in experimental colitis.