Sentences with phrase «experimental model systems»

«Biased» profiling of experimental model systems of cancer yields cleaner signatures as a result of the homogeneous genetic background.

The international endeavor taps into the efforts of more than 100 scientists across 33 institutions with a broad range of expertise to collectively tackle the challenge of developing methods to bring experimental model systems to the ocean.

Single - cell technologies will be applied to experimental model systems such as organoids, miniature organs grown in the petri dish from one or more cells.

Currently, researchers have access to powerful tools in biology to help them understand the ocean, such as microscopy and DNA sequencing, but are lacking essential tools in genetics to make robust experimental model systems.

Although the underlying mechanisms remain largely unknown, particularly in humans, mechanistic insights are emerging from experimental model systems, which may have implications for understanding disease and development.

Preclinical mouse tumour models therefore provide a critical intermediate experimental model system tying together more basic in vitro research with studies in humans, thereby providing bench - to - bedside translational oncology research.

1) The opening premise of the study is that «While a first pregnancy before age 22 lowers breast cancer risk, a pregnancy after age significantly increases life - long breast cancer risk», but the entire experimental model system used here compares the progression of oncogenic lesions in virgin versus 5 - 7 week young mice, presumably to «keep ageing - associated variables constant».

They have also succeeded in blocking the uptake route in experimental model systems, preventing the exosomes from activating cancer cells.

November 12, 2015 — The Gordon and Betty Moore Foundation's Marine Microbiology Initiative is investing eight million dollars over the next two years to support scientists, globally and at all career stages, to accelerate development of experimental model systems in marine microbial ecology.

We describe an experimental model system that definitively links surgery and the subsequent wound - healing response to the outgrowth of tumor cells at distant anatomical sites.

The researchers were looking at the formation of amorphous solids in general, and they used an experimental model system for hard spheres.

Fortunately, a similar situation exists in an experimental model system, the fruit fly, Drosophila melanogaster.

Institutions and organizations working on the experimental model systems with funding from the foundation, including principal investigators:

Importantly, the upregulation of Bcl - xL was not only observed in an experimental model system, but also in breast cancer patients.

Previosly in a preclinical study BRAF inhibitor - resistant mutated BRAF melanoma cells were developed as an experimental model system to mimic BRAF inhibitor - resistant melanoma patients and to study the mechanisms of resistance.