Sentences with phrase «experimenting with gene»

Elsewhere, the sinister Energyne Corporation — run by the unscrupulous but hugely wealthy Wyden siblings (really quite badly played by Malin Akerman and Jake Lacy)-- have been experimenting with gene - editing on their privately financed space station.

Malin Akerman (above) and Jake Lacy play - really quite badly - the hugely wealthy Wyden siblings who have been experimenting with gene - editing on their private space station

So when biologists experimenting with gene therapy want to insert a single strand into a cell, they often wind up injecting dozens.

Doctors have been experimenting with gene therapy to supply healthy copies of a gene to patients suffering from a genetic defect.

The scientists are also experimenting with gene therapy, using a harmless virus to deliver a normal copy of the normal CIB2 gene to baby mice that have the mutated version.

With no viable testing mechanism on the horizon, it is possible that at least one of the 10,000 - plus Olympic competitors in Beijing this summer will have experimented with gene doping.

With no viable testing mechanism on the horizon, the possibility remains that at least one of the 10,000 - plus Olympic competitors in Athens this summer will have experimented with gene doping.

Not exact matches

The probability of a randomly selected mutation in a randomly selected gene having precisely that effect is quite low, so just as with the stones in the field, a positive finding is more likely than not to be spurious — unless the experiment is unbelievably successful at sorting the wheat from the chaff.

Those who feel there is something «unnatural» about introducing human genes into animals or plants forget that we share a high proportion of our genes with these species already: it is precisely this collective heritage that allows experiments on frogs to spawn treatments for human cancer.

For their experiments, the researchers created hybrids of two genetically distinct mouse strains with a fully sequenced genome, allowing gene variants to be clearly assigned to the maternal or paternal allele.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cells.

NC State biologists experimented with either inhibiting or overexpressing the bellwether gene, which gives rise to a protein that helps convert nutrients into metabolic energy.

Other teams are trying to introduce the proteins encoded by the genes directly into cells, while Yamanaka is experimenting with «microRNAs» — snippets of RNA that help regulate gene activity.

After the landmark experiments with the GFP gene in the mid-1990s, «All of a sudden it became obvious that GFP was a wonderful tool,» Chalfie says.

So with frogs, for instance, she cut and pasted genes in experiments that sometimes led to the development of two - headed (or no - headed) tadpoles.

Animal experiments revealed that mice carrying a mutated SCN8A gene had reduced heart rate compared with their healthy littermates, and that administration of caffeine produced an abnormal heart rhythm known as accelerated idioventricular rhythm.

As the young Levitan found out in lab experiments, certain of these gene packs, called 2L - 1 and 3R - 1, help the flies cope better with high temperatures.

With hundreds of labs catching CRISPR fever since 2013, most experiments have altered one or two genes at a time, maxing out at five.

Experiments with these mice suggest TREM2 is important for steering microglia toward amyloid and turning on genes that rev up their cleanup capabilities.

In one experiment with human cells, a guide RNA should have led the Cas9 enzyme only to a gene on chromosome 2 (yellow bar), but it also directed the enzyme to many off - target sites (red) on several other chromosomes.

They compared the resulting gene expression patterns in all the parrot brains with neural tracing experiments in budgerigars.

Diamond's lab circumvented this problem by creating female mice that had a key interferon gene knocked out; in a second experiment, they treated pregnant animals with an anti-interferon antibody.

The object of the experiment is to mutate a gene in the bacteria, giving it antibiotic resistance, then prove it by dosing the cultures with antibiotics.

Experiments in cells with an inactivated form of Argonaute — which contributes only to the antiviral and not the gene regulation activity of RNAi — confirmed that they were observing an antiviral RNAi response.

The wild Asian banana Musa acuminata malaccensis — the genome of which was published last year (A. D'Hont Nature 488, 213 — 217; 2012)-- seems to be resistant, and researchers are experimenting with putting its resistance genes into the Cavendish.

In one of their experiments, team members compared mice with a normally functioning Pad4 gene to mice with a defective gene.

Liu's experiments began by breeding finches with a singular genetic mutation — the introduction of mHTT, the mutant human gene responsible for Huntington's disease.

It did not begin to seriously discuss the risks associated with using the approach to engineer genes that could quickly spread through wild populations — known as gene drives — until after experiments demonstrating the concept in fruit flies had been published in a peer - reviewed journal (V. M. Gantz & E. Bier Science 348,442 — 444; 2015).

Based on experiments with mice, some scientists had speculated that cilia nestled in a dimple at the top of the embryo called the node might push fluid down the left side of the embryo, carrying a signal that somehow triggers certain genes to activate.

In one experiment, Dangl's team found that Arabidopsis plants with mutant versions of the PHR1 gene not only had impaired phosphate stress responses, but also developed different communities of microbes in and around their roots when grown in a local native North Carolina soil.

Just a couple of months ago, a UK - based team were given the go - ahead to experiment on human embryos, with the aim of identifying genes linked to embryo health, fertility and miscarriage.

Surani tried the experiment the other way, too, producing fertilized eggs with two sets of genes from a male mouse.

The ideal way to identify a gene network in humans would require an impossible experiment: Take two families, each with dozens of identical twins, and have the families interbreed, combining the same sets of genes together over and over again.

By performing experiments in petri dishes and with mice, they found that panobinostat, a drug designed to change the way cells regulate genes, may be effective at inhibiting DIPG growth and extending survival rates.

The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the brain regulates connections between neurons.

In a closing set of experiments, the researchers examined neurons obtained from mice with the most common inherited form of ALS, one caused by mutations in a gene called SOD1.

«We can't know with absolute certainty the effects of these genes unless someone resurrects a complete woolly mammoth, but we can try to infer by doing experiments in the laboratory,» he said.

But if you knew that the effect of a drug had a lot to do with whether you inherited specific genes from your mother or father, then you could design an experiment that would include parents.

In separate experiments, they picked 13 other codons and substituted them for alternatives with the same function across 42 different E. coli genes.

Using experiments with fruit fly eggs, the team saw that Oskar binds to RNA within the cell — specifically three RNAs derived from genes also known to be important to germline development.

The Finnish researchers had used a set of «gene wrenches» called RNAi molecules, to turn off genes of interest, and with these additional experiments the researchers identified tracks leading to a nuclear protein and gene controller protein called SRF.

The experiment's final product is equivalent to the naturally occurring genetic code of M. genitalium, with two minor exceptions: The scientists disabled the gene that gave the bug power to infect human cells, and they added a few «watermarks,» short strips of signature genetic code that identify the product as man - made.

To address that puzzle, Alcino Silva, a neuroscientist at the University of California, Los Angeles, has been experimenting with mice that have mutations in their NF1 gene.

In the new experiment, vision scientist Gerald Jacobs at the University of California, Santa Barbara, teamed up with geneticist Jeremy Nathans at Johns Hopkins Medical School in Baltimore, Maryland, and other colleagues to add a human photopigment gene to mice.

«We did the same experiments with one drug that is known to inhibit conjugation and another that encourages resistance genes to be lost,» Lopatkin said.

Through a series of experiments with bacteria capable of conjugation, they show that all of the bacteria tested share genes fast enough to maintain resistance.

In experiments with mice, researchers have linked these genes to weight gain and even to the «lost in time» feeling of marijuana use, but they've had a harder time studying them in humans.

In experiments with mice, disruptions in clock genes can lead to obesity, although scientists don't yet understand the mechanism.

Now in experiments in mice reported this week in Cell Metabolism, researchers at Joslin Diabetes Centers have highlighted the ways in which the host's genes interact with the microbial genes to create such conditions, says senior author C. Ronald Kahn, M.D., Chief Academic Officer at Joslin Diabetes Center and Mary K. Iacocca Professor of Medicine at Harvard Medical School.

The experiments often require drastic steps (such as knocking out genes, killing cells with antibodies, sewing animals together) that are impossible in human beings.