«Single cell genomics can be applied to understand the
heterogeneity of
tumors, to
explain how genetically identical cells may show distinct behavior, and to explore the vast, uncharacterized microbial landscape.
In these cases, UroSEEK could be detecting clonal proliferations in the bladder epithelium that did not progress to cancer, and such proliferations may be more common in patients with BC than in the general population Risques and Kennedy, 2018Because only one biopsy from the primary
tumor was available for comparison, it is also possible that intratumoral
heterogeneity explains some of the discrepancies.