In fact, drastic reductions in caloric intake reduce
leptin levels, faster than could be
explained by body fat losses (the same goes for overfeeding, which increase
leptin levels faster than can be
explained by body fat gain).
Thus, it is possible that the CNS abnormalities observed in ME / CFS patients can be
explained, at least in part,
by the ability of
leptin and resistin to cross and / or disrupt the blood — brain barrier (46).