Sentences with phrase «explaining muscle weakness»
«Surprisingly, we found that the strength of the muscle itself was the same between the DS and control mice — suggesting that factors in the nervous system may play a more dominant role in explaining muscle weakness in DS,» said Cowley.
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The end result, which the new study helps to explain, is dysfunction of motor neurons that control muscle along with muscle atrophy and weakness.
«We also found that increasing muscle weakness — possibly due to decreasing testosterone concentration in the blood — could explain most of this relationship,» said Benjumin Hsu, MPH, the study's principal investigator and a PhD candidate at the University of Sydney.
Glass says that although his group's results do not explain why parabiosis works, they could help to explain the mechanism behind bimagrumab, an experimental Novartis treatment for muscle weakness and wasting.
This may indicate that neural activation of the muscle plays a greater role in explaining weakness in persons with DS.
«We now know that the muscle is not the major issue responsible for muscle weakness in DS mice,» explained Cowley.