FOXA1 activation, inducing enhancer reprogramming that endows a cancer cell with metastatic properties, is an epigenetic mechanism, as opposed to a genetic one, that
explains at least one mechanism of metastasis in this form of pancreatic cancer, and likely, other cancer
types as well.
The crushing defeat of the charter referendum in Massachusetts is
at least partially
explained by the political foolishness of narrowly focusing the charter movement on a certain
type of school to serve disadvantaged students.
(
explains the two main
types of people who become pharmacy technicians, and both are good for the profession)-- Pharmacy Technician Career in the News (Yahoo recently put out two articles on a career as a pharmacy technician)- Best Free Pharmacy App for Pharmacy Technicians — Pennsylvania Pharmacy Technician Registration Bill (another state creates more rigorous requirements for becoming a pharmacy technician, this is the trend and will most likely reach all states in the next 5 years)-- Tech - Check - Tech... Is it coming for pharmacy technicians (some states are moving towards this, my state is considering it)-- Top 5 Pharmacy Technician Websites (We list the top 5 sites for pharmacy technicians that you should
at least know about)-- Pharmacy Technician HQ August Update (Sharing the GOYA principle... you have to read to find out)-- Pharmacy Technician IT and Pharmacy School Q&A (Discusses a unique pharmacy technician role that has often resulted in a nice career for many pharmacy technicians I know)
These toxic stress - induced changes in brain structure and function mediate,
at least in part, the well - described relationship between adversity and altered life - course trajectories (see Fig 1).4, 6 A hyper - responsive or chronically activated stress response contributes to the inflammation and changes in immune function that are seen in those chronic, noncommunicable diseases often associated with childhood adversity, like chronic obstructive pulmonary disease (COPD), cirrhosis,
type II diabetes, depression, and cardiovascular disease.4, 6 Impairments in critical SE, language, and cognitive skills contribute to the fractured social networks often associated with childhood adversity, like school failure, poverty, divorce, homelessness, violence, and limited access to healthcare.4, 19,58 — 60 Finally, behavioral allostasis, or the adoption of potentially maladaptive behaviors to deal or cope with chronic stress, begins to
explain the association between childhood adversity and unhealthy lifestyles, like alcohol, tobacco, and substance abuse, promiscuity, gambling, and obesity.4, 6,61 Taken together, these 3 general classes of altered developmental outcomes (unhealthy lifestyles, fractured social networks, and changes in immune function) contribute to the development of noncommunicable diseases and encompass many of the morbidities associated epidemiologically with childhood adversity.4, 6